患者来源的异种移植：临床前癌症研究的一个有前景的资源。
Patient-derived xenografts: a promising resource for preclinical cancer research.
作者信息
Karamboulas Christina, Ailles Laurie
机构信息
Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
出版信息
Mol Cell Oncol. 2019 Jan 8;6(1):1558684. doi: 10.1080/23723556.2018.1558684. eCollection 2019.
Patient-derived xenograft tumors retain molecular and histopathological features of the originating tumor and are useful preclinical tools for drug discovery and assessment. We recently reported that 'rapid' engraftment of head and neck squamous cell carcinoma samples is highly prognostic and correlates with deregulation of the G1/S checkpoint. Tumors with genetic alterations in cyclinD1 ( and/or cyclin-dependent kinase inhibitor 2A ( are more likely to respond to abemaciclib.
患者来源的异种移植肿瘤保留了原发肿瘤的分子和组织病理学特征，是药物发现和评估中有用的临床前工具。我们最近报告说，头颈部鳞状细胞癌样本的“快速”植入具有高度预后性，并且与G1/S 检查点的失调相关。细胞周期蛋白D1（和/或细胞周期蛋白依赖性激酶抑制剂2A）发生基因改变的肿瘤更有可能对阿贝西利产生反应。
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