慢性卡介苗诱导的肉芽肿病小鼠肝脏中主要细胞外基质成分水平之间的相关性
Correlations between the Levels of the Main Extracellular Matrix Components in Mouse Liver in Chronic BCG-Induced Granulomatosis.
作者信息
Kim L B, Shkurupy V A, Putyatina A N
机构信息
Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
出版信息
Bull Exp Biol Med. 2019 Feb;166(4):469-472. doi: 10.1007/s10517-019-04374-7. Epub 2019 Feb 20.
Correlations between extracellular matrix components in mouse liver revealed the pathogenetically determined dynamic structure of these interrelations (some correlations appeared while others disappeared) at various terms of BCG-induced granulomatosis. The correlations between the studied parameters were strong during the first (postinfection days 3-10) and the second (postinfection days 60-90) periods but became moderate during the third period manifested by chronic inflammation (postinjection day 180). The greatest number of correlations was observed at the beginning of the stabilization period (postinjection day 60). At this period, the content of all structural components of hepatic proteoglycans closely correlated with that of hydroxyproline. These findings attested to systemic changes in metabolism of extracellular matrix components and interrelation between some structural units of proteoglycans in the liver and the components of extracellular matrix in the lungs. The common and typical organ-specific correlations in the liver and lungs suggest the existence of correlations between different organs during progression of BCG-induced granulomatosis.
小鼠肝脏细胞外基质成分之间的相关性揭示了卡介苗诱导的肉芽肿病不同阶段这些相互关系的发病机制决定的动态结构（一些相关性出现而另一些消失）。在第一个阶段（感染后3 - 10天）和第二个阶段（感染后60 - 90天），研究参数之间的相关性很强，但在以慢性炎症为特征的第三个阶段（注射后180天）相关性变弱。在稳定期开始时（注射后60天）观察到的相关性数量最多。在此期间，肝蛋白聚糖所有结构成分的含量与羟脯氨酸的含量密切相关。这些发现证明了细胞外基质成分代谢的系统性变化以及肝脏中蛋白聚糖的一些结构单元与肺中细胞外基质成分之间的相互关系。肝脏和肺中常见且典型的器官特异性相关性表明在卡介苗诱导的肉芽肿病进展过程中不同器官之间存在相关性。
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