铁催化的非活化烯烃的氨氢化和醚化反应。
Iron-Catalyzed Hydroamination and Hydroetherification of Unactivated Alkenes.
机构信息
Department of Chemistry , Indiana University , 800 East Kirkwood Avenue , Bloomington , Indiana 47405-7102 , United States.
出版信息
Org Lett. 2019 Mar 1;21(5):1547-1550. doi: 10.1021/acs.orglett.9b00427. Epub 2019 Feb 21.
Abstract
The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of catalysts to control selectivity and reactivity. Modern variants typically rely on noble metals that require different ligands for each class of hydrofunctionalization, thereby limiting generality. This Letter describes a general iron-based system that catalyzes the hydroamination and hydroetherification of simple unactivated olefins.
摘要
烯烃的水功能化已经探索了 100 多年，为增值产品提供了一种直接、原子经济的方法。虽然热力学上有利，但这类过程的动力学障碍需要使用催化剂来控制选择性和反应性。现代变体通常依赖于需要为每一类水功能化使用不同配体的贵金属，从而限制了通用性。本文描述了一种通用的铁基体系，它可以催化简单的未活化烯烃的氨氢化和醚化反应。
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