Department of Epidemiology and Statistics, School of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou City, Jiangsu Province, China.
Suzhou Industrial Park Centers for Disease Control and Prevention, Suzhou City, Jiangsu Province, China.
PLoS One. 2019 Feb 21;14(2):e0212702. doi: 10.1371/journal.pone.0212702. eCollection 2019.
More than 11 million people were estimated to be infected by Schistosoma japonicum in China before the 1950s. However, seldom studies have been conducted to evaluate the longitudinal effects of previous schistosome infection (PSI). We aimed to investigate the association between PSI and hyperuricemia in China.
From February 2013 to October 2013, 3,517 Chinese subjects (908 persons with PSI and 2,609 persons without PSI) were recruited from a prospective cohort study of "135". After two years, 113 and 462 participants had developed hyperuricemia in the persons with and without PSI, respectively. Multivariable logistic models were used to estimate Relative Ratios (RR) and 95% confidence intervals (CIs) for hyperuricemia.
The PSI participants had a decreased risk of hyperuricemia compared with those without PSI [adjusted RR (95%CI): 0.73 (0.55, 0.97)]. Within the PSI group, higher level of fasting plasma glucose was significantly associated with the reduced incidence of hyperuricemia in PSI population (RR: 0.40, 95% CI: 0.26-0.63). For females, hypertension, increased levels of serum creatinine and triglycerides were the risk factors for incident hyperuricemia in the PSI group.
Our results suggest that PSI is significantly associated with the lower incidence of hyperuricemia. Moreover, elevated fasting plasma glucose might prevent the onset of hyperuricemia in PSI population.
20 世纪 50 年代以前，估计中国有超过 1100 万人感染日本血吸虫。然而，很少有研究评估既往血吸虫感染（PSI）的纵向影响。我们旨在研究中国 PSI 与高尿酸血症之间的关系。
2013 年 2 月至 10 月，从“135”前瞻性队列研究中招募了 3517 名中国受试者（908 名有 PSI 和 2609 名无 PSI）。两年后，PSI 组和无 PSI 组分别有 113 名和 462 名参与者发展为高尿酸血症。多变量逻辑模型用于估计高尿酸血症的相对比值（RR）和 95%置信区间（CI）。
与无 PSI 组相比，PSI 组发生高尿酸血症的风险降低[校正 RR（95%CI）：0.73（0.55，0.97）]。在 PSI 组中，空腹血糖水平较高与 PSI 人群中高尿酸血症发生率降低显著相关（RR：0.40，95%CI：0.26-0.63）。对于女性，高血压、血清肌酐和甘油三酯水平升高是 PSI 组发生高尿酸血症的危险因素。
我们的结果表明，PSI 与较低的高尿酸血症发生率显著相关。此外，空腹血糖升高可能预防 PSI 人群中高尿酸血症的发生。
