Shen S-W, Lu Y, Li F, Shen Z-H, Xu M, Yao W-F, Feng Y-B, Yun J-T, Wang Y-P, Ling W, Qi H-J, Tong D-X
Wuxi No. 2 People's Hospital Affiliated to Nanjing Medical University, Wuxi City, Jiangsu Province, China.
Jiangsu Provincial Taihu Cadre's Sanatorium of Jiangsu Provincial People's Hospital Group, Wuxi City, Jiangsu Province, China.
Parasite Immunol. 2015 Jul;37(7):333-9. doi: 10.1111/pim.12187.
The association between potential long-term effects of previous schistosome infection (PSI) and the development of metabolic syndrome remains unknown. Therefore, we aimed to evaluate the association between them. Participants were from regions which were all reportedly heavily endemic for S. japonicum in China 40 years ago. One thousand five hundred and ninety-seven men were enrolled. Among these, 465 patients with PSI were selected as study subjects and 1132 subjects served as controls. We found PSI significantly correlated with lower prevalences of metabolic syndrome and its components, including central obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol, which indicates that the potential long-term effects of PSI may reduce the risk of metabolic syndrome. However, further studies are needed to investigate the protective immune effects of PSI.
既往血吸虫感染（PSI）的潜在长期影响与代谢综合征的发生之间的关联尚不清楚。因此，我们旨在评估它们之间的关联。研究对象来自据报道40年前中国日本血吸虫病高度流行的地区。共招募了1597名男性。其中，465例PSI患者被选为研究对象，1132例作为对照。我们发现PSI与代谢综合征及其组分（包括中心性肥胖、高甘油三酯血症和低高密度脂蛋白胆固醇）的较低患病率显著相关，这表明PSI的潜在长期影响可能会降低代谢综合征的风险。然而，需要进一步研究来探究PSI的保护性免疫作用。
