Spiridonov V K, Tolochko Z S, Korolenko T A
Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2019 Feb;166(4):436-439. doi: 10.1007/s10517-019-04367-6. Epub 2019 Feb 21.
The development of arterial hypertension in male Wistar rats with fructose-induced metabolic syndrome (12.5% of fructose solution as the only drinking source for 10 weeks) along with impaired glucose tolerance and increased serum concentration of triglycerides and LPO products caused a decrease in the content of serum blood calcitonin gene-related peptide (CGRP). Low-frequency transcutaneous electrical nerve stimulation (1 mA, 2 Hz, 10 min daily for 2 weeks) performed in 8 weeks after the beginning of fructose treatment reduced systolic BP and serum concentration of triglycerides and LPO produces and improved glucose tolerance. After stimulation, CGRP content in rats maintained on fructose diet returned to normal values and the content of nitric oxide metabolites increased. We hypothesize that CGRP and nitric oxide are involved in mechanisms mediating the therapeutic effect of low-frequency transcutaneous electrical nerve stimulation on arterial hypertension developing in metabolic syndrome.
给予果糖诱导的代谢综合征雄性Wistar大鼠（以12.5%的果糖溶液作为唯一饮水来源，持续10周），其出现动脉高血压，同时伴有糖耐量受损以及甘油三酯和脂质过氧化产物血清浓度升高，导致血清降钙素基因相关肽（CGRP）含量降低。在果糖治疗开始8周后进行低频经皮电神经刺激（1 mA，2 Hz，每天10分钟，持续2周），可降低收缩压、甘油三酯血清浓度和脂质过氧化产物，并改善糖耐量。刺激后，维持果糖饮食的大鼠体内CGRP含量恢复至正常水平，一氧化氮代谢产物含量增加。我们推测，CGRP和一氧化氮参与介导低频经皮电神经刺激对代谢综合征中动脉高血压的治疗作用机制。
