人类癌症、裸鼹鼠和动物类群更替。
Human cancer, the naked mole rat and faunal turnovers.
机构信息
Department of Laboratory Medicine, Lund University, Lund, Sweden.
Astrogeobiology Laboratory, Department of Physics, Lund University, Lund, Sweden.
出版信息
Cancer Med. 2019 Apr;8(4):1652-1654. doi: 10.1002/cam4.2011. Epub 2019 Feb 21.
Abstract
We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.
摘要
我们认为，人类进化过程中经常适应地质时期的环境变化，这影响了后代变异性和癌症抵抗力之间的权衡，从而有利于易患癌症的个体。我们将注意力转向一个因素，这个因素使高度抗癌的裸鼹鼠与大多数其他哺乳动物区别开来：自 3000 万到 5000 万年前以来，它的表型基本没有变化。专注于“活化石”动物的 DNA 稳定性机制的研究可能有助于我们找到预防和治疗癌症的工具。
相似文献
1
Human cancer, the naked mole rat and faunal turnovers.人类癌症、裸鼹鼠和动物类群更替。
Cancer Med. 2019 Apr;8(4):1652-1654. doi: 10.1002/cam4.2011. Epub 2019 Feb 21.
2
Four Cases of Spontaneous Neoplasia in the Naked Mole-Rat (Heterocephalus glaber), A Putative Cancer-Resistant Species.裸鼹鼠（Heterocephalus glaber）自发肿瘤四例，裸鼹鼠是一种假定的抗癌物种。
J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):38-43. doi: 10.1093/gerona/glw047. Epub 2016 Apr 29.
3
The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression.皮托悖论的多面性：癌症抑制进化的生活史模型。
Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). doi: 10.1098/rstb.2014.0221.
4
Spontaneous and Experimentally Induced Pathologies in the Naked Mole Rat (Heterocephalus glaber).裸鼹鼠（Heterocephalus glaber）的自发性和实验诱导性病理状况。
Biochemistry (Mosc). 2017 Dec;82(12):1504-1512. doi: 10.1134/S0006297917120094.
5
The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.裸鼹鼠基因组资源：促进癌症和长寿相关适应性分析。
Bioinformatics. 2014 Dec 15;30(24):3558-60. doi: 10.1093/bioinformatics/btu579. Epub 2014 Aug 28.
6
Insights into long noncoding RNAs of naked mole rat () and their potential association with cancer resistance.裸鼹鼠长链非编码RNA的见解及其与抗癌能力的潜在关联。
Epigenetics Chromatin. 2016 Nov 10;9:51. doi: 10.1186/s13072-016-0101-5. eCollection 2016.
7
Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber).咪喹莫特不会在裸鼹鼠（裸滨鼠）的皮肤中引发炎症反应。
BMC Res Notes. 2020 Sep 5;13(1):416. doi: 10.1186/s13104-020-05260-6.
8
Translational control in the naked mole-rat as a model highly resistant to cancer.裸鼹鼠作为一种具有高度抗癌能力的模型中的翻译调控。
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188455. doi: 10.1016/j.bbcan.2020.188455. Epub 2020 Oct 22.
9
The Mystery of Cancer Resistance: A Revelation Within Nature.癌症抗性之谜：自然中的启示
J Mol Evol. 2023 Apr;91(2):133-155. doi: 10.1007/s00239-023-10092-6. Epub 2023 Jan 24.
10
The Unusual Immune System of the Naked Mole-Rat.裸鼹鼠不寻常的免疫系统。
Adv Exp Med Biol. 2021;1319:315-327. doi: 10.1007/978-3-030-65943-1_12.
引用本文的文献
1
Low Cancer Incidence in Naked Mole-Rats May Be Related to Their Inability to Express the Warburg Effect.裸鼹鼠的低癌症发病率可能与其无法表现出瓦伯格效应有关。
Front Physiol. 2022 May 4;13:859820. doi: 10.3389/fphys.2022.859820. eCollection 2022.
2
Cancer, Retrogenes, and Evolution.癌症、逆转录基因与进化
Life (Basel). 2021 Jan 19;11(1):72. doi: 10.3390/life11010072.
本文引用的文献
1
The transition to modernity and chronic disease: mismatch and natural selection.向现代性与慢性病的转变：错配与自然选择。
Nat Rev Genet. 2018 Jul;19(7):419-430. doi: 10.1038/s41576-018-0012-3.
2
Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age.裸鼹鼠的死亡率与冈珀茨定律相悖，并不会随着年龄的增长而增加。
Elife. 2018 Jan 24;7:e31157. doi: 10.7554/eLife.31157.
3
Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis.原肠胚形成前期和神经发生期人类细胞中不同的突变率和机制。
Science. 2018 Feb 2;359(6375):550-555. doi: 10.1126/science.aan8690. Epub 2017 Dec 7.
4
Multi-organ Metastasis of Fibrolamellar Hepatocellular Carcinoma in a Malayan Gharial (Tomistoma schlegelii).马来鳄（马来长吻鳄）中纤维板层型肝细胞癌的多器官转移
J Comp Pathol. 2017 Aug-Oct;157(2-3):80-84. doi: 10.1016/j.jcpa.2017.06.007. Epub 2017 Jul 23.
5
Global clues to the nature of genomic mutations in humans.全球范围内人类基因组突变性质的线索。
Elife. 2017 May 17;6:e27605. doi: 10.7554/eLife.27605.
6
Differences between germline and somatic mutation rates in humans and mice.人类和小鼠种系与体细胞突变率的差异。
Nat Commun. 2017 May 9;8:15183. doi: 10.1038/ncomms15183.
7
Rapid evolution of the human mutation spectrum.人类突变谱的快速演变。
Elife. 2017 Apr 25;6:e24284. doi: 10.7554/eLife.24284.
8
Genetic drift, selection and the evolution of the mutation rate.遗传漂变、选择与突变率的进化。
Nat Rev Genet. 2016 Oct 14;17(11):704-714. doi: 10.1038/nrg.2016.104.
9
Variation in the molecular clock of primates.灵长类动物分子钟的变异。
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10607-12. doi: 10.1073/pnas.1600374113. Epub 2016 Sep 6.
10
The mutation rate in human evolution and demographic inference.人类进化中的突变率与人口统计学推断。
Curr Opin Genet Dev. 2016 Dec;41:36-43. doi: 10.1016/j.gde.2016.07.008. Epub 2016 Aug 31.
Zotero 插件