Department of Anesthesiology, Graduate School of Medicine, Chiba University, Japan.
Department of Anesthesiology, Graduate School of Medicine, Chiba University, Japan.
Respir Physiol Neurobiol. 2019 May;263:9-13. doi: 10.1016/j.resp.2019.02.004. Epub 2019 Feb 18.
Although mice are a commonly used animal species in experimental medicine, airway management of this species is not easy due to their small size. In order to develop a new method of tracheal intubation in mice, we produced a supraglottic intubation-aid conduit (SIAC) for mice, and tested the efficacy of this device in spontaneously breathing mice anesthetized with sevoflurane inhalation. The success rate of tracheal intubation with the crude prototype of the SIAC was 50% and adverse effects on respiration and some trauma in the upper airway were occasionally observed. After refining the size and shape of the SIAC, the success rate of tracheal intubation with the refined prototype of the SIAC was 100% without any serious adverse effects. This study showed that it is possible to produce a supraglottic airway device to aid tracheal intubation in mice and that the shape and size of the SIAC play a crucial role in successful tracheal intubation in mice.
虽然小鼠是实验医学中常用的动物物种，但由于其体型小，气道管理并不容易。为了开发一种新的小鼠气管插管方法，我们为小鼠制作了一个声门上气道辅助导管（SIAC），并在使用七氟醚吸入麻醉的自主呼吸小鼠中测试了该设备的效果。粗制原型 SIAC 的气管插管成功率为 50%，并且偶尔会观察到呼吸和上呼吸道的一些创伤的不良反应。在对 SIAC 的尺寸和形状进行改进后，精制原型 SIAC 的气管插管成功率达到 100%，没有任何严重的不良反应。这项研究表明，有可能生产出一种声门上气道装置来辅助小鼠的气管插管，并且 SIAC 的形状和尺寸在小鼠成功气管插管中起着关键作用。
