1 Suqian First Hospital, Suqian, Jiangsu, China.
2 Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
J Biomater Appl. 2019 Apr;33(9):1252-1264. doi: 10.1177/0885328219831391. Epub 2019 Feb 21.
Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mellitus and promoting insulin independence in patients, its widespread implementation has been severely constrained by instances of post-transplantation islet cell death, rejection, and severe adverse immune responses. Islet encapsulation is an active area of research aimed at shielding implanted islets from immunological rejection and inflammation while still allowing for effective insulin and nutrient exchange with donor cells. Given their promising physical and chemical properties, hydrogels have been a major subject of focus in the field of islet transplantation and encapsulation technology, offering promising advances towards immunologically privileged islet implants. The present review therefore summarizes the current state of research regarding the use of hydrogels in the context of islet transplantation, including both natural molecular hydrogels and artificial polymer hydrogels, with the goal of understanding the current strengths and weaknesses of this treatment strategy.
1 型糖尿病是一种严重的疾病，约占所有糖尿病病例的 10%，而且全球 1 型糖尿病的发病率在稳步上升，近期内没有治愈的希望。虽然胰岛移植已被证明是治疗 1 型糖尿病和促进患者胰岛素独立性的有效手段，但由于移植后胰岛细胞死亡、排斥和严重的免疫反应，其广泛实施受到严重限制。胰岛包封是一个活跃的研究领域，旨在屏蔽植入的胰岛免受免疫排斥和炎症的影响，同时仍然允许与供体细胞进行有效的胰岛素和营养物质交换。鉴于其有前途的物理和化学性质，水凝胶一直是胰岛移植和包封技术领域的主要研究重点，为免疫特惠胰岛植入物提供了有希望的进展。因此，本综述总结了水凝胶在胰岛移植中的应用研究现状，包括天然分子水凝胶和人工聚合物水凝胶，旨在了解这种治疗策略的当前优势和劣势。
