Ribeiro Rebecca Heidrich Thoen, Ribeiro Fernando Ambros, Silva Romeu Paulo Martins, Bortolini Miguel Júnior Sordi, Garrote-Filho Mario da Silva, Penha-Silva Nilson
Center for Health Sciences and Sports, Federal University of Acre, Rio Branco, AC, Brazil.
Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Clin Med Insights Ear Nose Throat. 2019 Feb 13;12:1179550619828683. doi: 10.1177/1179550619828683. eCollection 2019.
The objective of this study was to evaluate and correlate hematologic indices, vitamin B levels, and depression in patients with suspected reflux (LPR) treated with proton pump inhibitor (PPI).
This was a prospective study with a population (n = 23) consisted of patients with suspected LPR and treated with 2 daily doses of Omeprazole 40 mg (80 mg or full dose). The study volunteers performed a complete blood count and vitamin B dosage before and after 3 and 6 months of treatment, as well as depression screening using the Center of Epidemiologic Studies-Depression (CES-D) questionnaire before and after 6 months of treatment. Scores greater than 16 were considered as suggestive of depression.
The mean score on the CES-D scale of study participants at baseline significantly decreased after 6 months of treatment. A significant decrease was observed in the red blood cells count (RBC) after 6 months in relation to 3 months. Significant increases in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were observed from 3 months to 6 months in this study. Vitamin B levels increased significantly between baseline and after 6 months of treatment.
Decreased scores on the CES-D scale were associated with increased MCV values, with no association with vitamin B levels. However, vitamin B levels also increased significantly after 6 months of treatment with PPI.
本研究旨在评估接受质子泵抑制剂（PPI）治疗的疑似反流性喉炎（LPR）患者的血液学指标、维生素B水平及抑郁情况，并进行相关性分析。
这是一项前瞻性研究，研究对象为23例疑似LPR患者，每日服用2次40毫克奥美拉唑（80毫克或全剂量）。研究志愿者在治疗3个月和6个月前后进行全血细胞计数和维生素B检测，并在治疗6个月前后使用流行病学研究中心抑郁量表（CES-D）进行抑郁筛查。得分大于16分被视为提示抑郁。
治疗6个月后，研究参与者在CES-D量表上的基线平均得分显著降低。与3个月时相比，6个月时红细胞计数（RBC）显著降低。本研究中，从3个月到6个月，平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）显著增加。治疗6个月后，维生素B水平较基线显著升高。
CES-D量表得分降低与MCV值升高相关，与维生素B水平无关。然而，PPI治疗6个月后，维生素B水平也显著升高。
