Jiang Chunxiang, Jiang Lanlan, Qin Qingwu
Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Department of Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Evid Based Complement Alternat Med. 2019 Jan 17;2019:9580670. doi: 10.1155/2019/9580670. eCollection 2019.
The efficacy of conventional treatments plus acupuncture for asthma in adult and adolescent is uncertain. Literature reports are conflicting; therefore, the aim of this study was to determine the efficacy of conventional treatments plus acupuncture versus conventional treatments alone using a meta-analysis of all published randomized clinical trials (RCTs).
Two reviewers independently performed a comprehensive literature search from multiple electronic sources (1990-2018), including PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, and WanFang databases. RCTs in which adult and adolescent patients with asthma (age ≥12 years) were divided into conventional treatments plus acupuncture and conventional treatments alone were included.
Nine studies were included. The results showed that conventional treatments plus acupuncture as a complementary therapy could improve the symptom response rate (OR = 7.87, 95% CI = [4.13, 14.99], p < 0.00001) and significantly decrease interleukin-6 (IL-6) levels (MD = -11.42; 95% CI = [-15.28, -7.56], p < 0.00001). However, indices of pulmonary function, including the forced expiratory volume in one second (FEV) (MD = 0.22, 95% CI = [-0.11, 0.56], p = 0.19) and FEV/forced vital capacity (FVC) (MD = 8.62, 95% CI = [-0.35, 17.59], p = 0.06), failed to be improved with conventional treatments plus acupuncture.
Conventional treatments plus acupuncture are associated with significant benefits for adult and adolescent patients with asthma. Therefore, we suggest the use of conventional treatments plus acupuncture for asthma patients.
传统疗法联合针灸治疗成人及青少年哮喘的疗效尚不确定。文献报道相互矛盾；因此，本研究的目的是通过对所有已发表的随机临床试验（RCT）进行荟萃分析，确定传统疗法联合针灸与单纯传统疗法相比的疗效。
两名研究者独立地从多个电子资源库（1990 - 2018年）进行全面的文献检索，包括PubMed、EMBASE、Cochrane图书馆、科学网、中国知网和万方数据库。纳入将年龄≥12岁的成人及青少年哮喘患者分为传统疗法联合针灸组和单纯传统疗法组的RCT。
纳入9项研究。结果显示，传统疗法联合针灸作为一种辅助疗法可提高症状缓解率（OR = 7.87，95%CI = [4.13, 14.99]，p < 0.00001），并显著降低白细胞介素-6（IL-6）水平（MD = -11.42；95%CI = [-15.28, -7.56]，p < 0.00001）。然而，肺功能指标，包括一秒用力呼气量（FEV）（MD = 0.22，95%CI = [-0.11, 0.56]，p = 0.19）和FEV/用力肺活量（FVC）（MD = 8.62，95%CI = [-0.35, 17.59]，p = 0.
