Aniwan Satimai, Harmsen W Scott, Tremaine William J, Loftus Edward V
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.
Therap Adv Gastroenterol. 2019 Feb 6;12:1756284819827692. doi: 10.1177/1756284819827692. eCollection 2019.
Although inflammatory bowel disease (IBD) has been more predominant in white populations, an increasing incidence of IBD in nonwhites has been reported. We sought to evaluate the incidence rates and temporal trends of IBD by race and ethnicity.
The resources of the Rochester Epidemiologic Project were used to identify 814 county residents newly diagnosed with IBD from 1970 through 2010. Race was categorized into whites and nonwhites. Ethnicity was categorized into Hispanic and non-Hispanic. Incidence rates were estimated and adjusted for age and sex to the 2010 United States (US) population. Trends in incidence rates were evaluated by Poisson regression.
The adjusted annual incidence rate of IBD for whites was 21.6 cases per 100,000 person-years [95% confidence interval (CI), 20.0-23.1] and for nonwhites it was 13 per 100,000 (95% CI, 8.3-17.5). The incidence rates for whites and nonwhites increased by 39% and 134%, respectively, from 1970 through 2010. The adjusted annual incidence rate of IBD for Hispanics was 15 cases per 100,000 person-years (95% CI, 6.3-23.6) and for non-Hispanics was 20 per 100,000 (95% CI, 18.5-21.6). The incidence rate for Hispanics decreased by 56%, while the rate for non-Hispanics increased by 33%, from 1985 through 2010. In a Poisson regression, white race ( < 0.0001), a later year of diagnosis ( < 0.001), male sex ( < 0.001) and younger age ( = 0.009) were significantly associated with a higher incidence rate of IBD.
There were significant racial and ethnic differences in the incidence and temporal trends of IBD over the last four decades in this US population-based cohort.
尽管炎症性肠病（IBD）在白人人群中更为常见，但有报道称非白人中IBD的发病率也在上升。我们试图评估按种族和族裔划分的IBD发病率及时间趋势。
利用罗切斯特流行病学项目的资源，确定了1970年至2010年间814名新诊断为IBD的县居民。种族分为白人和非白人。族裔分为西班牙裔和非西班牙裔。估计发病率，并根据年龄和性别调整至2010年美国人口水平。通过泊松回归评估发病率趋势。
白人IBD的调整后年发病率为每10万人年21.6例[95%置信区间（CI），20.0 - 23.1]，非白人则为每10万人年13例（95%CI，8.3 - 17.5）。从1970年到2010年，白人和非白人的发病率分别上升了39%和134%。西班牙裔IBD的调整后年发病率为每10万人年15例（95%CI，6.3 - 23.6），非西班牙裔为每10万人年20例（95%CI，18.5 - 21.6）。从1985年到2010年，西班牙裔的发病率下降了56%，而非西班牙裔的发病率上升了33%。在泊松回归中，白人种族（<0.0001）、较晚的诊断年份（<0.001）、男性性别（<0.001）和较年轻的年龄（=0.009）与IBD较高的发病率显著相关。
在这个基于美国人群的队列中，过去四十年里IBD的发病率和时间趋势存在显著的种族和族裔差异。
