Ranjbar Akram, Vakilian Katayon
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Medical School, Arak University of Medical Sciences, Arak, Iran.
Interv Med Appl Sci. 2018 Dec;10(4):207-209. doi: 10.1556/1646.10.2018.38.
Considering that very few studies have been conducted on the effect of Entonox on oxidative stress markers, this study was conducted to compare these markers in natural vaginal delivery (NVD) with and without Entonox.
The present cohort study was conducted on 120 women in maternity wards divided into two groups, including an NVD group with and an NVD group without Entonox. After obtaining the mothers' written consent, 5 cc of venous blood was taken at the end of their second stage of labor for lipid peroxidation, thiol groups, and total antioxidant capacity tests. The data obtained were analyzed using descriptive (mean) and inferential (-test) statistics.
Lipid peroxide was 6.267 ± 5.39 in NVD without Entonox and 5.12 ± 3.89 in NVD with Entonox, suggesting the lack of a statistically significant difference ( = 0.191). Thiol marker was 0.34 ± 0.26 in NVD without and 0.26 ± 0.24 in NVD with Entonox, suggesting the lack of a statistically significant difference ( = 0.09).The FRAP results were 0.936 ± 0.696 in NVD without and 1.21 ± 0.89 in NVD with Entonox, suggesting the lack of a statistically significant difference ( = 0.06).
Entonox can be safely used in NVD without increasing the risk of oxidative stress.
鉴于关于恩托诺克斯对氧化应激标志物影响的研究极少，本研究旨在比较自然阴道分娩（NVD）中使用和不使用恩托诺克斯时的这些标志物。
本队列研究对产科病房的120名女性进行，分为两组，包括使用恩托诺克斯的NVD组和未使用恩托诺克斯的NVD组。在获得母亲的书面同意后，于第二产程结束时采集5毫升静脉血进行脂质过氧化、巯基和总抗氧化能力检测。所获数据采用描述性（均值）和推断性（t检验）统计方法进行分析。
未使用恩托诺克斯的NVD组脂质过氧化物为6.267±5.39，使用恩托诺克斯的NVD组为5.12±3.89，表明差异无统计学意义（P=0.191）。未使用恩托诺克斯的NVD组巯基标志物为0.34±0.26，使用恩托诺克斯的NVD组为0.26±0.24，表明差异无统计学意义（P=0.09）。未使用恩托诺克斯的NVD组FRAP结果为0.936±0.696，使用恩托诺克斯的NVD组为1.21±0.89，表明差异无统计学意义（P=0.06）。
恩托诺克斯可安全用于自然阴道分娩，而不会增加氧化应激风险。
