Chin Y H, Falanga V, Streilein J W, Sackstein R
Department of Microbiology, University of Miami School of Medicine, FL 33101.
Reg Immunol. 1988 Jul-Aug;1(1):78-83.
Lymphocyte migration is a critical component of a functional immune system. It increases the efficiency of the regional immune responses and disseminates locally induced effector cells to distant inflammatory sites. Central to the migratory process is the ability of lymphocytes to extravasate from the blood by selectively binding to segments of venules lined by high endothelium in lymph nodes and mucosal-associated lymphoid tissues. Recent studies have demonstrated that the specific recognition and adhesion of lymphocytes to high endothelial venules (HEV) is mediated by receptor/ligand systems that are different between lymph nodes (LN) and Peyer's patches (PP). The differential expression of lymphocyte surface receptors accounts for the preferential migration patterns of distinct lymphocyte subsets. More recently, the existence of specialized dermal endothelial cells in cutaneous tumors and inflamed skin that are capable of supporting lymphocyte adherence has been documented. This lymphocyte-endothelial cell interaction is an energy- and calcium-dependent process that involves surface glycoprotein and carbohydrates, requirements that are analogous to lymphocyte binding to HEV in LN and PP. Interestingly, antibodies directed against surface molecules mediating adhesion to HEV of LN and HEV of PP have no effect on lymphocyte binding to the dermal endothelium, suggesting that an additional receptor/ligand system promotes lymphocyte traffic into this site. Moreover, similar but additional receptor/ligand interactions may exist and may mediate lymphocyte migration into other sites. The identification and isolation of these receptor/ligand systems will provide important insights into both regional specialization of the normal immune response and pathophysiology of inflammatory diseases in diverse organs and tissues.
淋巴细胞迁移是功能性免疫系统的关键组成部分。它提高了局部免疫反应的效率，并将局部诱导的效应细胞传播到远处的炎症部位。迁移过程的核心是淋巴细胞通过选择性地结合淋巴结和黏膜相关淋巴组织中由高内皮细胞衬里的小静脉段从血液中渗出的能力。最近的研究表明，淋巴细胞与高内皮小静脉（HEV）的特异性识别和黏附是由淋巴结（LN）和派尔集合淋巴结（PP）之间不同的受体/配体系统介导的。淋巴细胞表面受体的差异表达解释了不同淋巴细胞亚群的优先迁移模式。最近，已经证明在皮肤肿瘤和炎症皮肤中存在能够支持淋巴细胞黏附的特殊真皮内皮细胞。这种淋巴细胞 - 内皮细胞相互作用是一个能量和钙依赖性过程，涉及表面糖蛋白和碳水化合物，这些要求类似于淋巴细胞与LN和PP中的HEV结合。有趣的是，针对介导与LN的HEV和PP的HEV黏附的表面分子的抗体对淋巴细胞与真皮内皮的结合没有影响，这表明另一种受体/配体系统促进淋巴细胞进入该部位。此外，可能存在类似但额外的受体/配体相互作用，并可能介导淋巴细胞迁移到其他部位。这些受体/配体系统的鉴定和分离将为正常免疫反应的区域特化以及不同器官和组织中炎症性疾病的病理生理学提供重要见解。
