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养老院药剂师对老年人用药管理实践的影响:一项对照试验。

The effect of a residential care pharmacist on medication administration practices in aged care: A controlled trial.

机构信息

Discipline of Pharmacy, Faculty of Health, University of Canberra, Bruce, Australian Capital Territory, Australia.

Discipline of Nursing, Faculty of Health, University of Canberra, Bruce, Australian Capital Territory, Australia.

出版信息

J Clin Pharm Ther. 2019 Aug;44(4):595-602. doi: 10.1111/jcpt.12822. Epub 2019 Feb 21.

Abstract

WHAT IS KNOWN AND OBJECTIVE

With the ageing of the population also comes increasing comorbidities and the use of multiple medications and administration methods, along with greater susceptibility to adverse drug reactions. Dosage form modification to facilitate drug administration in older adults can be potentially problematic as altering the original licensed formulation can affect medication safety and efficacy. The reporting of adverse drug reactions and medication incidents is a key strategy in avoiding preventable adverse drug events for aged care residents. This study evaluated the effect of an on-site clinical pharmacist on reducing inappropriate dosage form modification and staff time spent on medication administration, and optimizing the documentation of drug allergies, adverse drug reactions and medication incidents.

METHODS

A pilot-controlled trial was performed in a purposive sample of two residential aged care homes. Both homes belonged to the same organization; the study site had 104 beds and the control site had 100 beds. All permanent residents were eligible for inclusion in the study if written consent was provided. A residential care pharmacist position was implemented at the study site for six months, with a focus on performing medication reviews and quality improvement activities. Observational audits of medication rounds were performed, and documentation relating to allergies, adverse drug reactions, and medication incidents was obtained from both sites before and after the pharmacist trial period.

RESULTS

At the study site, there was a significant reduction over the trial in the proportion of inappropriate dosage form modification (from 24% to 0% of all dosage form modifications; P < 0.01). Mean time spent on medication rounds per resident reduced from 4.8 minutes per resident (SD 1.1) to 3.2 minutes per resident (SD 1.7) per round (P < 0.05). The incidence of previous allergy and adverse drug reaction documentation significantly improved from 77% of residents pre-study to 100% of residents post-study (P < 0.01). Mean monthly medication incident reports significantly improved from 13.3 (SD 7.4) pre-study to 25.7 (SD 10.8) post-study (P < 0.05). There was no change in these outcomes at the control site.

WHAT IS NEW AND CONCLUSION

Including a pharmacist in a residential aged care home can improve medication administration practices by reducing inappropriate dosage form modification and staff time spent on medication administration rounds, and increasing the documentation of resident allergies, adverse drug reactions and medication incidents. These findings warrant further exploration in a large randomized controlled trial.

摘要

已知和目的

随着人口老龄化,老年人的合并症增多,用药种类和给药途径增多,对药物不良反应的敏感性增加。为便于老年人给药而改变剂型可能会带来潜在问题,因为改变原批准的制剂形式会影响药物的安全性和疗效。报告药物不良反应和用药事件是避免老年护理居民发生可预防的药物不良事件的关键策略。本研究评估了驻场临床药剂师对减少不适当剂型修改和工作人员用于给药的时间的影响,以及优化药物过敏、药物不良反应和用药事件的记录。

方法

在两个有目的抽样的养老院进行了试点对照试验。两个养老院都属于同一个组织;研究点有 104 张床位,对照点有 100 张床位。如果书面同意,所有常住居民都有资格参加研究。在研究点设立了一名住宅护理药剂师职位,为期六个月,重点是进行药物审查和质量改进活动。对药物查房进行观察性审核,并在药剂师试验期前后从两个地点获取与过敏、药物不良反应和用药事件有关的记录。

结果

在研究点,试验期间不适当剂型修改的比例显著降低(所有剂型修改中从 24%降至 0%;P<0.01)。每位居民的药物查房时间从每位居民 4.8 分钟(SD 1.1)减少到每位居民 3.2 分钟(SD 1.7)(P<0.05)。居民既往过敏和药物不良反应记录的发生率从研究前的 77%显著提高到研究后的 100%(P<0.01)。每月药物不良事件报告的平均值从研究前的 13.3(SD 7.4)显著提高到研究后的 25.7(SD 10.8)(P<0.05)。对照点的这些结果没有变化。

创新和结论

在养老院中加入药剂师可以通过减少不适当的剂型修改和工作人员用于药物管理查房的时间,并增加居民过敏、药物不良反应和药物不良事件的记录,来改善药物管理实践。这些发现需要在大型随机对照试验中进一步探讨。

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