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用于自我监测血糖的智能手机比色检测系统的设计、制作与可行性分析。

Design, fabrication, and feasibility analysis of a colorimetric detection system with a smartphone for self-monitoring blood glucose.

机构信息

National Taiwan University of Science and Technology, Department of Mechanical Engineering Taipei, Taiwan.

iXensor Co. Ltd., Taipei, Taiwan.

出版信息

J Biomed Opt. 2019 Feb;24(2):1-7. doi: 10.1117/1.JBO.24.2.027002.

Abstract

Maintaining appropriate insulin levels is very important for diabetes patients. Effective monitoring of blood glucose can aid in maintaining the body's insulin level, and thus reduce disease severities, secondary complications, and related mortalities. However, existing blood glucose measurement devices are inconvenient to carry and involve complex procedures, reducing the willingness of diabetes patients to regularly measure blood glucose. We aim to provide a rapid, convenient, and portable meter for diabetes patients. We introduce an integrated blood glucose detection device (IBGDD) that has no electronic component and uses the optical sensing module of a smartphone to inspect colorimetric blood strips. To demonstrate accuracy conformance of the developed device to the ISO 15197:2013 standard for blood glucose measurement, 20 diabetes mellitus patients used the IBGDD with smartphones to measure their blood glucose level. The measurement results revealed an accuracy of 100%, completely satisfying the requirements of the ISO 15197:2013 standard. Overall, our specially designed IBGDD with a smartphone could achieve high accuracy and convenient usage for the measurement of blood glucose concentration. Furthermore, the device is highly portable and simple to operate. This contributes toward achieving self-monitoring of blood glucose by diabetes patients and improved mobile health in the future.

摘要

维持适当的胰岛素水平对糖尿病患者非常重要。有效的血糖监测有助于维持体内胰岛素水平,从而降低疾病严重程度、继发并发症和相关死亡率。然而,现有的血糖测量设备携带不便,操作复杂,降低了糖尿病患者定期测量血糖的意愿。我们旨在为糖尿病患者提供一种快速、方便、便携的血糖仪。我们介绍了一种集成的血糖检测设备(IBGDD),它没有电子元件,而是利用智能手机的光学传感模块来检测比色血条。为了证明所开发设备的准确性符合 ISO 15197:2013 血糖测量标准,20 名糖尿病患者使用带有智能手机的 IBGDD 测量他们的血糖水平。测量结果显示准确率为 100%,完全满足 ISO 15197:2013 标准的要求。总的来说,我们专门设计的带有智能手机的 IBGDD 可以实现高精度和方便的血糖浓度测量。此外,该设备体积小巧,操作简单。这有助于实现糖尿病患者的自我血糖监测和未来移动医疗的改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5812/6988182/95ed49a6305c/JBO-024-027002-g001.jpg

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