1 Division of Urology, Department of Surgery, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.
2 King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
J Endourol. 2019 Apr;33(4):319-324. doi: 10.1089/end.2019.0057. Epub 2019 Mar 21.
Although general guidelines exist directing the management of new/novel oral anticoagulants (NOACs) in the perioperative period for open/endoscopic procedures, no consensus exists for those patients being considered for shockwave lithotripsy (SWL). To gauge current practice, we administered a survey to the international endourologic community.
A web-based survey was sent to current Endourological Society members. Respondents were asked whether they would consider SWL in patients receiving NOACs, and if they used SWL how these agents were managed perioperatively. Respondents were also asked which physicians in the patients' circle of care managed the discontinuation and reinstitution of the drugs.
There were 165 respondents from 27 countries. Approximately 92.7% of urologists had access to SWL but only 53.4% indicated they would offer SWL to patients receiving NOACs. Among these urologists, 63.3% relied on internal medicine/hematology/cardiology colleagues to counsel patients on the discontinuation of NOACs pretreatment, whereas the majority (64%) handled the resumption guidance themselves. There was wide variability in the management of NOACs before lithotripsy, with discontinuation varying from 2 to 7 days. Resumption was more consistent, ranging from 1 to 2 days or when hematuria resolved. None of the respondents reported knowledge of adverse effects such as perinephric hematomas or cardiovascular morbidity.
A large percentage of globally surveyed endourologists do not offer SWL to patients who are taking NOACs. Among those that do offer SWL, there seems to be a absence of consensus on optimal duration of discontinuation, suggesting a need to establish evidence-based guidance to optimize patient outcomes.
尽管存在针对新/新型口服抗凝剂(NOAC)在开放/内镜手术围手术期管理的一般指南,但对于考虑行体外冲击波碎石术(SWL)的患者,尚无共识。为了评估当前的实践情况,我们向国际腔内泌尿外科界进行了一项调查。
我们向当前的泌尿外科学会成员发送了一项基于网络的调查。受访者被问及他们是否会考虑在接受 NOAC 治疗的患者中进行 SWL,如果他们使用 SWL,如何在围手术期管理这些药物。受访者还被问及患者的治疗圈中的哪些医生负责管理药物的停药和重新使用。
来自 27 个国家的 165 名受访者。大约 92.7%的泌尿科医生可以获得 SWL,但只有 53.4%的医生表示他们会为接受 NOAC 治疗的患者提供 SWL。在这些泌尿科医生中,63.3%依赖于内科/血液科/心脏病学的同事来指导患者停用 NOAC 治疗前的药物,而大多数(64%)则自行处理恢复指导。SWL 前 NOAC 的管理存在很大差异,停药时间从 2 天到 7 天不等。恢复时间较为一致,范围为 1 天到 2 天,或者血尿消退时。没有受访者报告过肾周血肿或心血管发病率等不良影响的知识。
全球调查的大多数腔内泌尿科医生不向服用 NOAC 的患者提供 SWL。在那些提供 SWL 的医生中,似乎对最佳停药时间缺乏共识,这表明需要制定循证指南,以优化患者结局。