褪黑素水平降低与子痫前期的发生相关：一项荟萃分析。
The reduction of melatonin levels is associated with the development of preeclampsia: a meta-analysis.
作者信息
Dou Yuanyan, Lin Binbin, Cheng Hui, Wang Changbao, Zhao Mingming, Zhang Jie, Wu Jing
机构信息
a School of Public Health , Medical College of Soochow University , Suzhou , China.
b School of Clinical Medicine , Medical College of Soochow University , Suzhou , China.
出版信息
Hypertens Pregnancy. 2019 May;38(2):65-72. doi: 10.1080/10641955.2019.1581215. Epub 2019 Feb 22.
OBJECTIVE
The aim of this analysis was to demonstrate the association between melatonin levels and the development of preeclampsia.
METHODS
Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated using a random effects model.
RESULTS
The pooled SMD between case and control was 1.40 (95% CI: 0.26, 2.55; P = 0.02). And the pooled SMD between mild PE and severe PE was 5.25 (95% CI: 1.5, 9.01; P = 0.006).
CONCLUSION
The meta-analysis illustrated that melatonin concentration was significantly lower in women with preeclampsia, and correlated with the severity of the disease.
目的
本分析旨在证明褪黑素水平与子痫前期发生之间的关联。
方法
采用随机效应模型计算标准化均数差（SMD）及95%置信区间（CI）。
结果
病例组与对照组之间的合并SMD为1.40（95%CI：0.26，2.55；P = 0.02）。轻度子痫前期与重度子痫前期之间的合并SMD为5.25（95%CI：1.5，9.01；P = 0.006）。
结论
荟萃分析表明，子痫前期女性的褪黑素浓度显著降低，且与疾病严重程度相关。
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