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鼓室内注射类固醇治疗难治性突发性感音神经性听力损失:使用西尔弗斯坦导管的12年经验

Intratympanic steroid therapy for refractory sudden sensory hearing loss: a 12-year experience with the Silverstein catheter.

作者信息

Vanwijck France, Rogister Florence, Pierre Barriat Sébastien, Camby Severine, Lefebvre Philippe

机构信息

a Department of Otorhinolaryngology , CHU Liege , Liège , Belgium.

出版信息

Acta Otolaryngol. 2019 Feb;139(2):111-116. doi: 10.1080/00016489.2018.1532107. Epub 2019 Feb 22.

Abstract

BACKGROUND

Sudden sensorineural hearing loss (SSNHL) is commonly encountered in clinical practice.

AIM/OBJECTIVE: Determine if local administration of corticosteroids to the inner ear can improve hearing and speech intelligibility after the failure of conventional treatment for SSNHL loss when administered for 10 days after the onset of the hearing loss in a large cohort of 77 patients.

MATERIALS AND METHODS

A Silverstein MicroWick™ was placed under local anesthesia and endoscopic control in the round window niche, allowing self-administration of methylprednisolone twice daily for four weeks.

RESULTS

An improvement of the pure tone average was shown in 31% of patients. Speech intelligibility improved significantly in 55% of the total cohort and in 34% of the population with a stable pure tone average. Among the 77 patients, 22% used a hearing aid. Only 14% of the patients were hearing-aid users in the group with an improvement in speech intelligibility as opposed to 31% in the failure group.

CONCLUSION AND SIGNIFICANCE

Local administration of steroids to the inner ear through the round window route improves hearing and speech intelligibility in patients after failure of conventional therapy. The use of a hearing aid was reduced by 50% when speech intelligibility was improved.

摘要

背景

突发性感音神经性听力损失(SSNHL)在临床实践中较为常见。

目的

在77例患者的大型队列中,确定在听力损失发作后10天开始给予内耳局部注射皮质类固醇,在常规治疗SSNHL失败后是否能改善听力和言语清晰度。

材料与方法

在局部麻醉和内镜控制下,将Silverstein MicroWick™置于圆窗龛内,允许患者每天自行注射两次甲泼尼龙,持续四周。

结果

31%的患者纯音平均听阈有所改善。55%的总队列患者以及34%纯音平均听阈稳定的患者言语清晰度显著提高。77例患者中,22%使用助听器。在言语清晰度改善的组中,只有14%的患者使用助听器,而在未改善组中这一比例为31%。

结论与意义

通过圆窗途径向内耳局部注射类固醇可改善常规治疗失败患者的听力和言语清晰度。当言语清晰度提高时,助听器的使用减少了50%。

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