Li Ming, Mu Yurong, Cai Hua, Wu Han, Ding Yanyan
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Neurosci. 2022 Jan 31;15:831591. doi: 10.3389/fncel.2021.831591. eCollection 2021.
Auditory diseases are disabling public health problems that afflict a significant number of people worldwide, and they remain largely incurable until now. Driven by continuous innovation in the fields of chemistry, physics, and materials science, novel materials that can be applied to hearing diseases are constantly emerging. In contrast to conventional materials, new materials are easily accessible, inexpensive, non-invasive, with better acoustic therapy effects and weaker immune rejection after implantation. When new materials are used to treat auditory diseases, the wound healing, infection prevention, disease recurrence, hair cell regeneration, functional recovery, and other aspects have been significantly improved. Despite these advances, clinical success has been limited, largely due to issues regarding a lack of effectiveness and safety. With ever-developing scientific research, more novel materials will be facilitated into clinical use in the future.
听觉疾病是困扰全球大量人群的致残性公共卫生问题，迄今为止，这些疾病在很大程度上仍无法治愈。在化学、物理和材料科学领域持续创新的推动下，可应用于听力疾病的新型材料不断涌现。与传统材料相比，新材料易于获取、价格低廉、无创，具有更好的声学治疗效果，植入后免疫排斥较弱。当使用新材料治疗听觉疾病时，伤口愈合、感染预防、疾病复发、毛细胞再生、功能恢复等方面都有了显著改善。尽管取得了这些进展，但临床成功仍然有限，这主要是由于有效性和安全性方面的问题。随着科学研究的不断发展，未来将有更多新型材料被推广应用于临床。
