1 Department of Radiology, 306 Hospital of PLA , Beijing , China.
2 Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology , Beijing , China.
Dentomaxillofac Radiol. 2019 Jul;48(5):20180416. doi: 10.1259/dmfr.20180416. Epub 2019 Mar 5.
: To investigate the relationship between maximum standardized uptake value (SUVmax) of F-FDG PET/CT and clinicopathological features of oral squamous cell carcinoma (OSCC), in order to formulate a better clinical guideline.
: In 104 patients with OSCC confirmed by pathology, there were 67 males and 37 females (age, 33-76 years; mean age, 56 years).FDG, 18-fludeoxyglucose (F-FDG) PET/CT manifestations and the clinicopathological features of the 104 patients were retrospectively analysed. Single-factor analysis and multiple regression analysis were conducted on possible factors influencing primary tumour SUVmax, including gender, age, smoking history, tumour location, tumour size, histological differentiation, TNM stage, T stage, N stage. Diagnostic performance of SUVmax for invading peri-tissue of OSCC was measured by the area under receiver operating characteristic curve, and sensitivity and specificity were determined at the Youdons index.
: The single-analysis results showed that SUVmax was correlated with the histological differentiation, tumour size, TNM stage, T stage, N stage( < 0.05), yet it was not correlated with gender, age, smoking history, tumour location ( > 0.05). Multivariate liner regression analysis showed that tumour size, TNM stage were influencing factors independent of primary tumour SUVmax ( < 0.05). Primary tumour SUVmax had predictive value for invading peri-tissue of OSCC. When the cutoff value was 7.98, the diagnostic efficiency was the highest, with the sensitivity being 90.0％ and the specificity being 76.2%.
: OSCC F-FDG PET/CT SUVmax is higher among patients with larger tumour size, poorer stage, and that primary tumour SUVmax is of important significance in predicting invading peri-tissue.
探讨氟代脱氧葡萄糖（18F-FDG）正电子发射断层扫描（PET）/CT 最大标准化摄取值（SUVmax）与口腔鳞状细胞癌（OSCC）临床病理特征的关系，以期制定更好的临床指南。
对 104 例经病理证实的 OSCC 患者的 FDG、18F-FDG PET/CT 表现及临床病理特征进行回顾性分析。对可能影响原发肿瘤 SUVmax 的因素，包括性别、年龄、吸烟史、肿瘤部位、肿瘤大小、组织学分化、TNM 分期、T 分期、N 分期进行单因素分析和多元回归分析。采用受试者工作特征曲线下面积测量 SUVmax 对 OSCC 侵犯周围组织的诊断效能，并采用 Youdons 指数确定敏感度和特异度。
单因素分析结果显示，SUVmax 与组织学分化、肿瘤大小、TNM 分期、T 分期、N 分期有关（ < 0.05），而与性别、年龄、吸烟史、肿瘤部位无关（ > 0.05）。多元线性回归分析显示，肿瘤大小、TNM 分期是影响原发肿瘤 SUVmax 的独立因素（ < 0.05）。原发肿瘤 SUVmax 对 OSCC 侵犯周围组织有预测价值。当截断值为 7.98 时，诊断效率最高，敏感度为 90.0％，特异度为 76.2％。
OSCC 患者 F-FDG PET/CT SUVmax 随肿瘤体积增大、分期升高而升高，原发肿瘤 SUVmax 对预测侵犯周围组织具有重要意义。
