Latzko Lukas, Schöpf Bernd, Weissensteiner Hansi, Fazzini Federica, Fendt Liane, Steiner Eberhard, Bruckmoser Emanuel, Schäfer Georg, Moncayo Roy-Cesar, Klocker Helmut, Laimer Johannes
University Hospital for Craniomaxillofacial and Oral Surgery, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, A-6020 Innsbruck, Austria.
Cancers (Basel). 2021 May 10;13(9):2273. doi: 10.3390/cancers13092273.
Under aerobic conditions, some cancers switch to glycolysis to cover their energy requirements. Taking advantage of this process, functional imaging techniques such as PET-CT can be used to detect and assess tumorous tissues. The aim of this study was to investigate standardized uptake values and mitochondrial DNA mutations in oral squamous cell carcinoma. A cohort of 57 patients underwent [F]FDG-PET-CT and standardized uptake values were collected. In 15 patients, data on mitochondrial DNA mutations of the tumor were available. Kaplan-Meier curves were calculated, and correlation analyses as well as univariate Cox proportional hazard models were performed. Using ROC analysis to determine a statistical threshold for SUVmax in PET investigations, a cut-off value was determined at 9.765 MB/mL. Survival analysis for SUVmax in these groups showed a Hazard Ratio of 4 (95% CI 1.7-9) in the high SUVmax group with 5-year survival rates of 23.5% ( = 0.00042). For SUVmax and clinicopathological tumor features, significant correlations were found. A tendency towards higher mtDNA heteroplasmy levels in high SUVmax groups could be observed. We were able to confirm the prognostic value of SUVmax in OSCC, showing higher survival rates at lower SUVmax levels. Correlations between SUVmax and distinct tumor characteristics were highly significant, providing evidence that SUVmax may act as a reliable diagnostic parameter. Correlation analysis of mtDNA mutations suggests an influence on metabolic activity in OSCC.
在有氧条件下，一些癌症会转向糖酵解以满足其能量需求。利用这一过程，正电子发射断层扫描-计算机断层扫描（PET-CT）等功能成像技术可用于检测和评估肿瘤组织。本研究的目的是调查口腔鳞状细胞癌中的标准化摄取值和线粒体DNA突变。57名患者组成的队列接受了[F]氟代脱氧葡萄糖正电子发射断层扫描-计算机断层扫描（[F]FDG-PET-CT）并收集了标准化摄取值。15名患者可获得肿瘤线粒体DNA突变的数据。计算了Kaplan-Meier曲线，并进行了相关性分析和单变量Cox比例风险模型分析。使用受试者工作特征（ROC）分析来确定PET检查中SUVmax的统计阈值，确定截止值为9.765 MB/mL。这些组中SUVmax的生存分析显示，高SUVmax组的风险比为4（95%置信区间1.7-9），5年生存率为23.5%（P = 0.00042）。对于SUVmax与临床病理肿瘤特征，发现了显著相关性。在高SUVmax组中可观察到线粒体DNA异质性水平有升高趋势。我们能够证实SUVmax在口腔鳞状细胞癌中的预后价值，显示在较低SUVmax水平下生存率更高。SUVmax与不同肿瘤特征之间的相关性非常显著，这表明SUVmax可能是一个可靠的诊断参数。线粒体DNA突变的相关性分析表明其对口腔鳞状细胞癌的代谢活性有影响。
