Department of Kinesiology and Health Sciences, William and Mary, Williamsburg, Virginia, United States of America.
Department of Economics, William and Mary, Williamsburg, Virginia, United States of America.
PLoS One. 2019 Feb 22;14(2):e0212890. doi: 10.1371/journal.pone.0212890. eCollection 2019.
To test the impact of a nationwide Long-Lasting Insecticidal Nets [LLINs] distribution program in the Democratic Republic of Congo [DRC] on all-cause under-five child mortality exploiting subnational variation in malaria endemicity and the timing in the scale-up of the program across provinces.
Geospatial Impact Evaluation using a difference-in-differences approach.
Democratic Republic of the Congo.
52,656 children sampled in the 2007 and 2013/2014 DRC Demographic and Health Surveys.
The analysis provides plausibly causal estimates of both average treatment effects of the LLIN distribution campaign and geospatial heterogeneity in these effects based on malaria endemicity. It compares the under-five, all-cause mortality for children pre- and post-LLIN campaign relative to children in those areas that had not yet been exposed to the campaign using a difference-in-differences model and controlling for year- and province-fixed effects, and province-level trends in mortality.
We find that the campaign led to a 41% decline [3.7 percentage points, 95% CI 1.3 to 6.0] in under-5 mortality risk among children living in rural areas with malaria ecology above the sample median. Results were robust to controlling for household assets and the presence of other health aid programs. No effect was detected in children living in areas with malaria ecology below the median.
The findings of this paper make important contributions to the evidence base for the effectiveness of large scale-national LLIN campaigns against malaria. We found that the program was effective in areas of the DRC with the highest underlying risk of malaria. Targeting bednets to areas with greatest underlying risk for malaria may help to increase the efficiency of increasingly limited malaria resources but should be balanced against other malaria control concerns.
利用疟疾流行程度的次国家级差异和该方案在各省扩大规模的时间,检验刚果民主共和国(DRC)全国长效驱虫蚊帐(LLINs)分发计划对所有原因导致的五岁以下儿童死亡率的影响。
使用差异中的差异方法进行地理空间影响评估。
刚果民主共和国。
2007 年和 2013/2014 年刚果民主共和国人口与健康调查中抽样的 52656 名儿童。
该分析提供了 LLIN 分发运动的平均处理效果的合理因果估计以及基于疟疾流行程度的这些效果的地理空间异质性。它通过差异中的差异模型,比较了蚊帐运动前后儿童与尚未接触该运动的地区儿童的五岁以下全因死亡率,控制了年度和省级固定效应以及省级死亡率趋势。
我们发现,对于生活在疟疾生态高于样本中位数的农村地区的儿童,该运动导致五岁以下儿童死亡率风险降低了 41%[3.7 个百分点,95%置信区间 1.3 至 6.0]。在控制家庭资产和其他卫生援助计划的存在后,结果仍然稳健。在疟疾生态低于中位数的儿童中未检测到效果。
本文的研究结果为大规模国家 LLIN 运动对抗疟疾的有效性提供了重要的证据基础。我们发现,该方案在刚果民主共和国疟疾风险最高的地区是有效的。将蚊帐针对疟疾风险最大的地区可能有助于提高日益有限的疟疾资源的效率,但应与其他疟疾控制问题相平衡。