Facultad de Medicina, Universidad de Atacama, Copayapu 485, 1531772 Copiapo, Chile.
Department of Materials Engineering, University of British Columbia, Vancouver, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, Canada.
Biochim Biophys Acta Mol Basis Dis. 2020 Feb 1;1866(2):165414. doi: 10.1016/j.bbadis.2019.02.009. Epub 2019 Feb 19.
In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. During pregnancy, several metabolic changes occur, in which endothelial function decisively participates. Similarly, when pregnancy metabolic disorders occur, endothelial dysfunction plays a key role in pathogenesis. This review outlines the main findings regarding endothelial dysfunction in three main metabolic pathological conditions observed during pregnancy: gestational diabetes, hypertensive disorders, and obesity and hyperlipidemia. Organ, histological and cellular characteristics were thoroughly described. Also, we focused in discussing the underlying molecular mechanisms involved in the cellular signaling pathways that mediate responses in these pathological conditions.
近年来，血管内皮作为妊娠疾病发生和发展的关键因素引起了关注。内皮作为一种内分泌器官，通过响应代谢状态的变化来维持体内平衡。然而，在代谢紊乱中，内皮细胞会出现功能障碍，丧失正常的反应能力。在妊娠期间，会发生多种代谢变化，其中内皮功能会决定性地参与。同样，当发生妊娠代谢紊乱时，内皮功能障碍在发病机制中起着关键作用。本综述概述了在妊娠期间观察到的三种主要代谢病理状况（妊娠期糖尿病、高血压疾病和肥胖伴高脂血症）中内皮功能障碍的主要发现。对器官、组织学和细胞特征进行了详细描述。此外，我们还重点讨论了参与细胞信号通路的潜在分子机制，这些信号通路介导了这些病理状况下的反应。
