撒哈拉以南非洲女性的高血压相关合并症和并发症:简要综述

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review.

作者信息

Hahka Taija M, Slotkowski Rebecca A, Akbar Anum, VanOrmer Matt C, Sembajwe Lawrence Fred, Ssekandi Abdul M, Namaganda Agnes, Muwonge Haruna, Kasolo Josephine N, Nakimuli Annettee, Mwesigwa Naome, Ishimwe Jeanne A, Kalyesubula Robert, Kirabo Annet, Anderson Berry Ann L, Patel Kaushik P

机构信息

Department of Cellular and Integrative Physiology (T.M.H., A.L.A.B., K.P.P.), University of Nebraska Medical Center, Omaha, NE.

Department of Pediatrics (T.M.H., R.A.S., A.A., M.C.V., A.L.A.B.), University of Nebraska Medical Center, Omaha, NE.

出版信息

Circ Res. 2024 Feb 16;134(4):459-473. doi: 10.1161/CIRCRESAHA.123.324077. Epub 2024 Feb 15.

Abstract

Hypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress test of the cardiovascular system and can be the first instance in which cardiovascular disease is clinically apparent. In SSA, women experience a higher incidence of HDP compared with other African regions. However, the region has yet to adopt treatment and preventative strategies for HDP. This delay stems from insufficient awareness, lack of clinical screening for hypertension, and lack of prevention programs. In this brief literature review, we will address the long-term consequences of hypertension and HDP in women. We evaluate the effects of uncontrolled hypertension in SSA by including research on heart disease, stroke, kidney disease, peripheral arterial disease, and HDP. Limitations exist in the number of studies from SSA; therefore, we will use data from countries across the globe, comparing and contrasting approaches in similar and dissimilar populations. Our review highlights an urgent need to prioritize public health, clinical, and bench research to discover cost-effective preventative and treatment strategies that will improve the lives of women living with hypertension in SSA.

摘要

高血压是女性心血管疾病的主要病因,撒哈拉以南非洲(SSA)国家的高血压发病率位居世界前列。在全球范围内,扩大对高血压及其合并症的病因、管理以及认识,是减轻其危害、降低发病率和死亡率并提高个人生活质量的有效策略。妊娠高血压疾病(HDPs)是高血压中一个特别重要的子集,因为妊娠是心血管系统的一项重大压力测试,并且可能是心血管疾病首次在临床上显现的情况。在撒哈拉以南非洲,与其他非洲地区相比,女性患HDP的发病率更高。然而,该地区尚未采用针对HDP的治疗和预防策略。这种延迟源于认识不足、缺乏高血压临床筛查以及缺乏预防项目。在这篇简短的文献综述中,我们将探讨高血压和HDP对女性的长期影响。我们通过纳入有关心脏病、中风、肾病、外周动脉疾病和HDP的研究,评估撒哈拉以南非洲地区未控制的高血压的影响。撒哈拉以南非洲地区的研究数量存在局限性;因此,我们将使用全球各国的数据,比较和对比相似及不同人群中的方法。我们的综述强调迫切需要优先开展公共卫生、临床和基础研究,以发现具有成本效益的预防和治疗策略,从而改善撒哈拉以南非洲地区高血压女性的生活。

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