Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, 80309 United States of America.
Nanotechnology. 2019 Jun 28;30(26):264002. doi: 10.1088/1361-6528/ab096b. Epub 2019 Feb 22.
Nanostructured devices are able to foster the technology for cell membrane poration. With the size smaller than a cell, nanostructures allow efficient poration on the cell membrane. Emerging nanostructures with various physical transduction have been demonstrated to accommodate effective intracellular delivery. Aside from improving poration and intracellular delivery performance, nanostructured devices also allow for the discovery of novel physiochemical phenomena and the biological response of the cell. This article provides a brief introduction to the principles of nanostructured devices for cell poration and outlines the intracellular delivery capability of the technology. In the future, we envision more exploration on new nanostructure designs and creative applications in biomedical fields.
纳米结构器件能够促进细胞膜穿孔技术的发展。由于其尺寸小于细胞，纳米结构可以有效地在细胞膜上穿孔。已经证明，具有各种物理转导功能的新兴纳米结构可以实现有效的细胞内递药。除了提高穿孔和细胞内递药性能外，纳米结构器件还允许发现新的物理化学现象和细胞的生物学反应。本文简要介绍了纳米结构器件用于细胞穿孔的原理，并概述了该技术的细胞内递药能力。在未来，我们期望在生物医学领域对新的纳米结构设计和创新应用进行更多的探索。
