School of Biomedical Sciences and Pharmacy, the University of Newcastle, Callaghan, NSW, 2308, Australia.
Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW, 2308, Australia.
Sci Rep. 2019 Feb 22;9(1):2564. doi: 10.1038/s41598-019-38860-9.
Circular RNAs (circRNAs) are covalently closed structural isoforms of linear mRNA which have been observed across a broad range of species and tissues. Here, we provide a comprehensive circRNAs expression catalogue for the rat including 8 organs of both sexes during 4 developmental stages using a public RNAseq dataset. These analyses revealed thousands of circular RNA species, many expressed in an organ-specific manner along with their host genes which were enriched with tissue-specific biological functions. A large number of circRNAs also displayed a developmental-dependent expression pattern and are accumulated during ageing. CircRNAs also displayed some sexually dimorphic expression, with gender associated differences observed in various tissues and developmental stages. These observations suggest that circRNAs are dynamically expressed in a spatial-, temporal- and gender-specific manner in mammals, and may have important biological function in differentiation, development and aging.
环状 RNA（circRNAs）是线性 mRNA 的共价闭合结构异构体，已在广泛的物种和组织中观察到。在这里，我们使用公共 RNAseq 数据集，为大鼠提供了一个包括 4 个发育阶段的 8 种雌雄两性器官的全面的 circRNAs 表达目录。这些分析揭示了数千种环状 RNA 种类，许多种以组织特异性方式表达，与其宿主基因一起富集了组织特异性的生物学功能。大量的 circRNAs 也表现出发育依赖性的表达模式，并在衰老过程中积累。circRNAs 也表现出一些性别二态性表达，在不同的组织和发育阶段观察到与性别相关的差异。这些观察结果表明，circRNAs 在哺乳动物中以空间、时间和性别特异性的方式动态表达，并且在分化、发育和衰老过程中可能具有重要的生物学功能。
