Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Intensive Care in Hematologic and Oncologic Patients (iCHOP), Cologne, Germany.
Ann Hematol. 2019 May;98(5):1051-1069. doi: 10.1007/s00277-019-03622-0. Epub 2019 Feb 22.
Sepsis and septic shock are major causes of mortality during chemotherapy-induced neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting characteristics and prompt management is most important. Improved management of sepsis during neutropenia may reduce the mortality of cancer therapies. However, optimal management may differ between neutropenic and non-neutropenic patients. The aim of the current guideline is to give evidence-based recommendations for hematologists, oncologists, and intensive care physicians on how to manage adult patients with neutropenia and sepsis.
脓毒症和脓毒性休克是恶性肿瘤化疗诱导性中性粒细胞减少症期间导致死亡的主要原因，这些疾病需要紧急治疗。因此，了解其表现特征和及时管理是最重要的。改善中性粒细胞减少症期间脓毒症的管理可能会降低癌症治疗的死亡率。然而，中性粒细胞减少症和非中性粒细胞减少症患者的最佳管理可能不同。本指南的目的是为血液科医生、肿瘤科医生和重症监护医生提供循证建议，指导如何管理中性粒细胞减少症和脓毒症的成年患者。
