Post Graduation Program in Medical Sciences.
Post Graduation Program in Cardiovascular Sciences.
J Nutr. 2019 Mar 1;149(3):372-380. doi: 10.1093/jn/nxy289.
Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Although few studies have actually reported alterations of DNA methylation via methyl donor nutrient intake, emerging evidence indicates that nutritional modification of the microbiome can affect one-carbon metabolism and the capacity to methylate the genome in CKD. In this review, we discuss the nutritional modifications that may affect one-carbon metabolism and the possible impact of methyl donor nutrients on the microbiome, CKD, and its phenotype.
表观遗传改变，如与 DNA 甲基化相关的改变，可能为与疾病相关的基因表达改变相关的并发症提供分子解释，例如慢性肾脏病（CKD）。尽管在尿毒症环境中观察到 DNA 低甲基化和高甲基化，但这仍然只是表观遗传景观的一个方面，也是与 CKD 相关的任何生化失调的一个方面。然而，尿毒症促进的改变对调节基因表达的表观遗传景观的作用仍然是一个新颖且研究甚少的领域。尽管很少有研究通过甲基供体营养素的摄入实际报告 DNA 甲基化的改变，但新出现的证据表明，微生物组的营养修饰可以影响一碳代谢和在 CKD 中基因组甲基化的能力。在这篇综述中，我们讨论了可能影响一碳代谢的营养修饰以及甲基供体营养素对微生物组、CKD 及其表型的可能影响。
