Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, USA.
Nat Rev Genet. 2020 Dec;21(12):737-753. doi: 10.1038/s41576-020-0270-8. Epub 2020 Sep 9.
Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These inputs - which include both nutrient availability as a result of diet and growth factor signalling - are implicated in linking the environment to the maintenance of cellular homeostasis and cell identity. Recent studies have demonstrated that these inputs are much broader than had previously been known, encompassing metabolism from a wide variety of sources, including alcohol and microbiotal metabolism. These factors modify DNA and histones and exert specific effects on cell biology, systemic physiology and pathology. In this Review, we discuss the nature of these molecular networks, highlight their role in mediating cellular responses and explore their modifiability through dietary and pharmacological interventions.
通过细胞代谢作用于染色质的分子输入物是表观基因组的修饰物。这些输入物包括饮食导致的营养供应和生长因子信号，它们与环境联系在一起，以维持细胞内稳态和细胞身份。最近的研究表明，这些输入物比以前所知的要广泛得多，包括来自各种来源的代谢物，如酒精和微生物代谢物。这些因素修饰 DNA 和组蛋白，并对细胞生物学、系统生理学和病理学产生特定影响。在这篇综述中，我们讨论了这些分子网络的性质，强调了它们在介导细胞反应中的作用，并探讨了通过饮食和药理学干预来改变它们的可能性。
