鉴定出酿脓链球菌中两个新的核心染色体编码超抗原；speQ 和 speR。
Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR.
机构信息
Department of Infectious Diseases, Imperial College London, London W12 0NN, UK.
Department of Infectious Diseases, Imperial College London, London W12 0NN, UK; Department of Molecular Biology & Biotechnology, The Florey Institute, University of Sheffield, Sheffield S10 2TN, UK.
出版信息
J Infect. 2019 May;78(5):358-363. doi: 10.1016/j.jinf.2019.02.005. Epub 2019 Feb 20.
Superantigens are ubiquitous within the Streptococcus pyogenes genome, which suggests that superantigen-mediated T-cell activation provides a significant selective advantage. S. pyogenes can carry a variable complement of the 11 known superantigens. We have identified two novel S. pyogenes superantigens, denoted speQ and speR, adjacent to each other in the core-chromosome of isolates belonging to eleven different emm-types. Although distinct from other superantigens, speQ and speR were most closely related to speK and speJ, respectively. Recombinant SPEQ and SPER were mitogenic towards human peripheral blood mononuclear cells at ng/ml concentrations, and SPER was found to be more mitogenic than SPEQ.
超抗原广泛存在于酿脓链球菌基因组中，这表明超抗原介导的 T 细胞激活提供了显著的选择优势。酿脓链球菌可以携带 11 种已知超抗原的可变组合。我们在属于 11 种不同 emm 型别的分离株的核心染色体中发现了两个新的酿脓链球菌超抗原，分别命名为 speQ 和 speR。虽然与其他超抗原不同，但 speQ 和 speR 分别与 speK 和 speJ 最为密切相关。重组 SPEQ 和 SPER 在 ng/ml 浓度下对人外周血单个核细胞具有有丝分裂原活性，并且发现 SPER 比 SPEQ 更具有有丝分裂原活性。
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