Institute of Chemistry, University of Białystok, Ciołkowskiego Street 1K, 15-245, Białystok, Poland.
Institute of Chemistry, University of Białystok, Ciołkowskiego Street 1K, 15-245, Białystok, Poland.
J Steroid Biochem Mol Biol. 2019 May;189:65-72. doi: 10.1016/j.jsbmb.2019.02.006. Epub 2019 Feb 20.
Imidazolium salts reveal interesting biological properties, especially regarding antitumor and antimicrobial activities. Two series of imidazolium salts based on steroids were obtained in an efficient and convenient synthesis. They were biologically tested to evaluate their antibacterial and antifungal properties. The activities of new salts, especially in relation to Gram-positive bacterial strains are comparable to the activities of known antibiotics. The most promising activity was that against C. albicans, which exceeded the antifungal activity of commonly used drugs. Some of the new salts exhibited improved antifungal activities against phytopathogenic fungi: B. cinerea and C. beticola. Our research showed that new compounds could be potentially useful as antifungal antibiotics or inhibiting agents against pathogenic fungi.
咪唑盐具有有趣的生物特性，特别是在抗肿瘤和抗菌活性方面。我们通过一种高效便捷的合成方法得到了基于甾体的两类咪唑盐。我们对它们进行了生物测试，以评估它们的抗菌和抗真菌特性。这些新盐的活性，尤其是对革兰氏阳性细菌菌株的活性，可与已知抗生素相媲美。最有前途的活性是对 C. albicans 的活性，超过了常用药物的抗真菌活性。一些新盐对植物病原菌真菌（B. cinerea 和 C. beticola）显示出了改善的抗真菌活性。我们的研究表明，这些新化合物可能具有作为抗真菌抗生素或抗真菌抑制剂的潜力。
