Kirkman B R, Whelan W J
FEBS Lett. 1986 Jan 1;194(1):6-11. doi: 10.1016/0014-5793(86)80041-2.
There have been several reports of the incorporation of glucosamine into liver glycogen by an intraperitoneal injection of galactosamine, but it has not previously been considered that glucosamine is a normal component of liver glycogen. We now report that glucosamine occurs endogenously in rabbit- and pig-liver glycogens in the amount of about 1 nmol per 10 mg glycogen. Like the glucosamine incorporated by exogenous administration of galactosamine, the endogenous glucosamine takes the place of 1,4-linked alpha-glucose residues. It is found in both the outer and inner chains of the glycogen molecule.
已有多篇报道称，通过腹腔注射半乳糖胺可使氨基葡萄糖掺入肝糖原中，但此前并未认为氨基葡萄糖是肝糖原的正常成分。我们现在报告，氨基葡萄糖内源性地存在于兔肝和猪肝糖原中，每10毫克糖原中约含1纳摩尔。与通过外源性给予半乳糖胺掺入的氨基葡萄糖一样，内源性氨基葡萄糖取代了1,4-连接的α-葡萄糖残基。它存在于糖原分子的外链和内链中。
