铜绿假单胞菌的藻酸盐与从大鼠肺中分离出的两种形式的肝素结合凝集素的关联。
Association of alginate from Pseudomonas aeruginosa with two forms of heparin-binding lectin isolated from rat lung.
作者信息
Ceri H, McArthur H A, Whitfield C
出版信息
Infect Immun. 1986 Jan;51(1):1-5. doi: 10.1128/iai.51.1.1-5.1986.
Abstract
An endogenous heparin-binding lectin activity isolated from rat lung was separated into two distinct isolectin forms which showed subtle changes in carbohydrate specificity. The two lectin forms displayed different specificities toward alginic acid-purified cystic fibrosis isolates of Pseudomonas aeruginosa when assayed by inhibition of both hemagglutination and [3H]heparin binding. This ability of isolectin forms to show higher affinity toward alginic acid from certain P. aeruginosa strains may suggest that there is a selective mechanism in the colonization of patients with cystic fibrosis.
摘要
从大鼠肺中分离出的一种内源性肝素结合凝集素活性被分为两种不同的同工凝集素形式，它们在碳水化合物特异性上表现出细微变化。当通过抑制血凝和[3H]肝素结合进行测定时，这两种凝集素形式对藻酸纯化的铜绿假单胞菌囊性纤维化分离株表现出不同的特异性。同工凝集素形式对某些铜绿假单胞菌菌株的藻酸表现出更高亲和力的这种能力，可能表明囊性纤维化患者的定植存在一种选择性机制。
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本文引用的文献
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Heparin-inhibitable lectin. Purification from chicken liver and embryonic chicken muscle.肝素抑制性凝集素。从鸡肝和鸡胚胎肌肉中纯化。
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Interaction of a rat lung lectin with the exopolysaccharides of Pseudomonas aeruginosa.大鼠肺凝集素与铜绿假单胞菌胞外多糖的相互作用。
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