Implementation of preventive measures against tick-borne infections in a non-endemic area for tick-borne encephalitis-Results from a population-based survey in Lower Saxony, Germany.

Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are the most common tick-borne diseases in Germany. While for LB only non-specific prevention strategies exist, TBE can be additionally prevented by vaccination. It is unclear to which extent non-specific prevention strategies are applied by individuals living in non-endemic areas for TBE in Germany, and whether TBE vaccination status affects their implementation. Participants of the HaBIDS panel (Hygiene and Behavior Infectious Diseases Study) from four counties of Lower Saxony were invited to fill out a questionnaire on their TBE vaccination status, their LB diagnoses as well as their knowledge, attitudes, and practice related to prevention measures for tick-borne diseases. Based on self-reported data we estimated cumulative lifetime incidence (CUM) and incidence of LB as well as TBE vaccination coverage. One year later, participants received a supplementary questionnaire focusing on reasons for vaccination against TBE and compliance with the vaccination schedule. 1,573 (74.2% of those invited) panel members aged 18-69 years participated in this study. Of these, 22.8% reported to have ever been vaccinated against TBE. The estimated CUM of LB was 5.1% (95%-CI: 4.1%-6.4%), and the incidence was 1.09 per 1,000 person years (95%-CI: 0.87-1.36). 98% of participants knew that LB is transmitted by the bite of an infected tick, but about 50% didn't know that TBE vaccination does not protect against LB. Even though about 80% of study participants were convinced that recommended non-specific prevention strategies were indeed protective, a much lower proportion implemented them. TBE-vaccinated participants were better informed about tick-borne diseases compared to non-vaccinated participants, whereby being vaccinated did not negatively affect implementation of non-specific prevention strategies. Based on data from the supplementary questionnaire, traveling to endemic areas (75.3%) was the main reason for TBE vaccination; 33.0% of those vaccinated had a complete vaccination schedule with three doses. Our study in a TBE non-endemic area revealed deficits in knowledge about which pathogens are covered by TBE vaccination, and a lack in the implementation of non-specific prevention measures. TBE vaccination was not associated with a reduced uptake of non-specific prevention measures.