儿童脊柱硬膜外脓肿:病例报告及文献综述

Spinal Epidural Abscess in Children: Case Report and Review of the Literature.

作者信息

Houston Rebecca, Gagliardo Christina, Vassallo Sheryl, Wynne Peter J, Mazzola Catherine A

机构信息

Rowan University School of Medicine (UMDNJ), Stratford, New Jersey, USA.

Division of Pediatric Infectious Diseases, Goryeb Children's Hospital, Atlantic Health System, Morristown, New Jersey, USA; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

World Neurosurg. 2019 Jun;126:453-460. doi: 10.1016/j.wneu.2019.01.294. Epub 2019 Feb 22.

Abstract

BACKGROUND

Spinal epidural abscess (SEA) is a rare but serious infection in the epidural space along the spinal cord. SEA should be considered in patients with backache, fever, neurological deficits and/or spinal tenderness. Early diagnosis is imperative to prevent permanent neurological sequelae.

CASE DESCRIPTION

We report a case of lumbar SEA in a 13-year-old girl who was immunocompetent and presented with spinal tenderness, back pain and 4 days of fever. A lumbar magnetic resonance imaging demonstrated an epidural abscess from L3-S1. She had emergent surgical intervention. Cultures grew methicillin-susceptible Staphylococcus aureus. She was also given long-term systemic antibiotics and she made a complete recovery within 2 months.

CONCLUSIONS

SEA in an immunocompetent pediatric without risk factors is an extremely rare condition. In the English-language literature, there are only 30 reported cases in the past 19 years; our case brings the total to 31. Non-surgical treatment has been successful in both adult and pediatric patients under certain conditions. Still, there exists a risk of deterioration with non-surgical management, even in patients for whom treatment is begun in the absence of neurologic deficits. Tracking neurological deficits in children can be challenging, particularly in young children who are non-verbal and not yet ambulating, and a reliable neurologic examination is a critical component of non-surgical care. In consideration of these facts and the accelerated time frame of deterioration, once neurologic deficits are present, surgery plus systemic antibiotics remains the standard of care for pediatric SEA patients, with each individual case meriting review of the full clinical picture.

摘要

背景

脊髓硬膜外脓肿(SEA)是脊髓硬膜外间隙一种罕见但严重的感染。对于出现背痛、发热、神经功能缺损和/或脊柱压痛的患者应考虑SEA。早期诊断对于预防永久性神经后遗症至关重要。

病例描述

我们报告一例13岁免疫功能正常女孩的腰椎SEA病例,该女孩表现为脊柱压痛、背痛及4天发热。腰椎磁共振成像显示L3-S1水平硬膜外脓肿。她接受了急诊手术干预。培养结果显示为对甲氧西林敏感的金黄色葡萄球菌。她还接受了长期全身性抗生素治疗,并在2个月内完全康复。

结论

无危险因素的免疫功能正常儿童SEA极为罕见。在英文文献中,过去19年仅有30例报道;我们的病例使总数达到31例。在某些情况下,非手术治疗在成人和儿童患者中均已取得成功。然而,即使在无神经功能缺损时开始治疗的患者中,非手术治疗仍存在病情恶化风险。追踪儿童神经功能缺损具有挑战性,尤其是对于不会说话且尚未行走的幼儿,可靠的神经学检查是非手术治疗的关键组成部分。鉴于这些事实以及病情恶化的加速进程,一旦出现神经功能缺损,手术加全身性抗生素治疗仍是儿童SEA患者的标准治疗方案,每个病例都值得全面回顾临床情况。

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