Department of Intensive Care, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland.
Institute for Infectious Diseases, University of Bern, Friedbuehlstrasse 51, 3010 Bern, Switzerland.
J Crit Care. 2019 Jun;51:99-104. doi: 10.1016/j.jcrc.2019.02.019. Epub 2019 Feb 13.
Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. Possible factors contributing to infection are underlying psychiatric disease resulting in institutionalization of respective patients, and polytoxicomania. Controlled data on the therapy of severe adenovirus infections are lacking and remains experimental. In conclusion, data on HAdV-B21 infections causing severe pneumonia or ARDS are scarce. Controlled clinical trials on the therapy of adenovirus pneumonia are non existent and thus there is no established therapy so far. ICU physicians should be aware of this potentially devastating disease and further studies are needed.
人腺病毒 B21 感染引起的严重肺炎和急性呼吸窘迫综合征（HAdV-B21）是一种罕见但具有破坏性的疾病，可迅速发展为多器官衰竭和死亡。然而，到目前为止，仅有少数病例报告。感染似乎与感染危重患者的疾病严重程度增加和死亡率升高有关。可能导致感染的因素包括导致患者住院的潜在精神疾病和多种药物滥用。严重腺病毒感染的治疗的对照数据缺乏，仍处于实验阶段。总之，关于导致严重肺炎或急性呼吸窘迫综合征的 HAdV-B21 感染的数据很少。腺病毒肺炎治疗的对照临床试验尚未存在，因此到目前为止还没有确立的治疗方法。重症监护病房医生应该意识到这种潜在的破坏性疾病，需要进一步研究。
