Medical Biology Research Center, Kermanshah University of Medical sciences, Kermanshah, Iran.
Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2019 Apr;112:108690. doi: 10.1016/j.biopha.2019.108690. Epub 2019 Feb 22.
Cancer cells can adapt to low energy sources in the face of ATP depletion as well as to their high levels of ROS by altering their metabolism and energy production networks which might also have a role in determining cell fate and developing drug resistance. Cancer cells are generally characterized by increased glycolysis. This is while; cancer stem cells (CSCs) exhibit an enhanced pentose phosphate pathway (PPP) metabolism. Based on the current literature, we suggest that cancer cells when encountering ROS, first increase the glycolysis rate and then following the continuation of oxidative stress, the metabolic balance is skewed from glycolysis to PPP. Therefore, we hypothesize in this review that in cancer cells this metabolic deviation during persistent oxidative stress might be a sign of cancer cells' shift towards CSCs, an issue that might be pivotal in more effective targeting of cancer cells and CSCs.
癌细胞在面对 ATP 耗竭以及高水平 ROS 的情况下，可以通过改变代谢和能量产生网络来适应低能量来源，这可能也在决定细胞命运和产生耐药性方面发挥作用。癌细胞通常表现为糖酵解增加。而癌症干细胞 (CSC) 则表现出增强的磷酸戊糖途径 (PPP) 代谢。根据目前的文献，我们提出，当癌细胞遇到 ROS 时，首先会增加糖酵解速率，然后随着氧化应激的持续，代谢平衡从糖酵解偏向 PPP。因此，我们在这篇综述中假设，在持续氧化应激过程中，癌细胞的这种代谢偏差可能是癌细胞向 CSC 转变的标志，这在更有效地靶向癌细胞和 CSC 方面可能是至关重要的。
