Długosz-Lisiecka Magdalena, Jakubowska Teresa, Zbrojewska Magdalena
Lodz University of Technology, Institute of Applied Radiation Chemistry, Wróblewskiego 15, 90-924, Lodz, Poland.
Lodz University of Technology, Institute of Applied Radiation Chemistry, Wróblewskiego 15, 90-924, Lodz, Poland; Mikołaj Kopernik Provincial Multidisciplinary Center of Oncology and Traumatology, ul. Pabianicka 62, 93-513, Lodz, Poland.
Appl Radiat Isot. 2019 May;147:48-53. doi: 10.1016/j.apradiso.2019.02.007. Epub 2019 Feb 5.
Cd isotopes (Cd and Cd) are generated from the silver target body during the bombardment of [O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([F]FDG) for PET (Positron Emission Tomography) diagnosis. Cadmium isotopes contribute significantly to the total activity of generated impurities and, due to being potentially radiotoxic to living organisms, they should be effectively reduced from FDG to prevent accidental injection of even small concentrations into patients. Purification of the final [F]FDG can be based on a set of columns, fulfilling various functions in the cleaning process. To assess cadmium impurities and the efficiency of the purification process, a low background gamma spectrometry system with high resolution has been applied. Even activity of 3.5 kBq and 290 kBq has been measured on QMA (Sep-Pak Light Accell Plus QMA) columns for Cd and Cd isotopes, respectively. Cd activity in the five column set was higher than that of Cd. The rate of F production process was about 1 GBq/min, while that of Cd and Cd radionuclides was about 4.2 kBq/min and 50 Bq/min respectively. The same purification efficiency of both isotopes has been obtained at each step of the process. The production rate of Cd and Cd radionuclides was insignificant compared to the F production rate. Therefore [F]FDG final product for use in injections before PET diagnostics was efficiently purified from cadmium radionuclide impurities.
在用于正电子发射断层扫描（PET）诊断的2-[18F]氟-2-脱氧-D-葡萄糖（[F]FDG）常规生产过程中，用[O]水轰击银靶体时会产生镉同位素（Cd和Cd）。镉同位素对生成杂质的总活度有显著贡献，并且由于对生物体可能具有放射性毒性，应从FDG中有效去除它们，以防止即使是低浓度的镉意外注入患者体内。最终[F]FDG的纯化可以基于一组在净化过程中发挥各种功能的柱。为了评估镉杂质和纯化过程的效率，应用了一种具有高分辨率的低本底伽马能谱系统。在用于Cd和Cd同位素的QMA（Sep-Pak Light Accell Plus QMA）柱上分别测量到了3.5 kBq和290 kBq的活度。五柱组中Cd的活度高于Cd。F生产过程的速率约为1 GBq/min，而Cd和Cd放射性核素的速率分别约为4.2 kBq/min和50 Bq/min。在该过程的每个步骤中，两种同位素都获得了相同的纯化效率。与F的生产速率相比，Cd和Cd放射性核素的生产速率微不足道。因此，用于PET诊断前注射的[F]FDG最终产品已有效地从镉放射性核素杂质中纯化出来。
