Chang Gung Medical Education Research Centre (CG-MERC), Chang Gung Memorial Hospital Taoyuan Branch, Taoyuan, Taiwan.
BMJ Open. 2019 Feb 22;9(2):e025801. doi: 10.1136/bmjopen-2018-025801.
Stem cell research (SCR) and the biomedical potential of developing therapies are crucial topics in biomedicine. Like other biotechnologies, stem cells are context specific entities understood through local conceptualisations of culture, politics, nationhood, as well as their perceived therapeutic efficacy. There is a need to recognise how these developments are understood within the healthcare community and by those who may use them. This protocol describes a systematic literature review that aims to explore healthcare professionals', healthcare students', patients', and donors' perceptions of SCR and therapy (SCR/T) and the factors that influence their perceptions.
Following Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines a systematic review will be undertaken. Web of Science, Scopus, Medline+Journals @Ovid and Ariti Library will be systematically searched for studies on healthcare professionals', healthcare students', patients' and donors' perceptions of SCR and developing therapies. All articles will be screened by a researcher for inclusion and evaluation based on 12 criteria for evaluating qualitative research. At least 20% of articles will also be reviewed by a second researcher and any disagreement will be solved via consensus. Data extracted from the articles will be analysed using thematic synthesis enabling the identification of concepts across studies and the development of new theory.
As part of a larger research project, ethical approval has been provided by the Institutional Research Board (IRB) at Chang Gung Memorial Hospital. This review will be able to determine the impact that certain perceptions of SCR/T will have on the development of future medical knowledge and practice. The results of the study will be published in a peer-reviewed journal and disseminated at relevant conferences.
CRD42018103627.
干细胞研究（SCR）和开发疗法的生物医学潜力是生物医学中的关键主题。与其他生物技术一样，干细胞是通过文化、政治、国家的局部概念化以及它们被认为的治疗效果来理解的特定于上下文的实体。有必要认识到这些发展在医疗保健界以及可能使用它们的人当中是如何被理解的。本方案描述了一项系统文献综述，旨在探讨医疗保健专业人员、医疗保健学生、患者和供者对 SCR 和治疗（SCR/T）的看法，以及影响他们看法的因素。
根据系统评价和荟萃分析的首选报告项目指南，将进行系统综述。将通过 Web of Science、Scopus、Medline+Journals@Ovid 和 Ariti 图书馆对医疗保健专业人员、医疗保健学生、患者和供者对 SCR 和开发疗法的看法进行系统搜索。根据评估定性研究的 12 项标准，将由一名研究人员筛选所有文章是否纳入和评估。至少有 20%的文章也将由第二名研究人员进行审查，如果有任何分歧，将通过协商解决。从文章中提取的数据将使用主题综合分析进行分析，从而识别研究之间的概念，并发展新的理论。
作为一个更大的研究项目的一部分，长庚纪念医院机构研究委员会（IRB）已提供了伦理批准。这项综述将能够确定对 SCR/T 的某些看法将对未来医学知识和实践的发展产生何种影响。该研究的结果将发表在同行评议的期刊上，并在相关会议上传播。
PROSPERO 注册号：CRD42018103627。
