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Concomitant Treatment of Hepatitis C Virus and Diffuse Large B-Cell Lymphoma with Direct-Acting Antivirals in HIV Coinfection: A Case Report.HIV合并感染中丙型肝炎病毒与弥漫性大B细胞淋巴瘤的直接抗病毒药物联合治疗：一例报告

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958218822062. doi: 10.1177/2325958218822062.

2

Direct-Acting Antiretroviral Therapy in Renal Transplant Recipients With Human Immunodeficiency Virus-Hepatitis C Virus Coinfection: Report of Our Experience and Literature Review.接受抗逆转录病毒治疗的合并人类免疫缺陷病毒和丙型肝炎病毒感染的肾移植受者：我们的经验报告及文献综述

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3

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Gut Liver. 2018 Nov 15;12(6):694-703. doi: 10.5009/gnl18004.

4

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HIV infection does not increase the risk of liver complications in hepatitis C virus-infected patient with advanced fibrosis, after sustained virological response with direct-acting antivirals.HIV 感染不会增加 ADV 治疗后 HCV 感染伴有晚期纤维化患者的肝脏并发症风险。

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Efficacy of Ledipasvir and Sofosbuvir Treatment of HCV Infection in Patients Coinfected With HBV.利巴韦林联合索菲布韦治疗乙型肝炎病毒合并丙型肝炎病毒感染的疗效。

Gastroenterology. 2018 Mar;154(4):989-997. doi: 10.1053/j.gastro.2017.11.011. Epub 2017 Nov 22.

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Clinical Characteristics and Treatment Outcomes of Patients with Hepatitis C Virus and Human Immunodeficiency Virus Coinfection: Experience at a Single Center in Korea.韩国某单一中心丙型肝炎病毒和人类免疫缺陷病毒合并感染患者的临床特征和治疗结局。

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Management of drug interactions with direct-acting antivirals in Dutch HIV/hepatitis C virus-coinfected patients: adequate but not perfect.荷兰 HIV/丙型肝炎病毒合并感染患者中直接作用抗病毒药物药物相互作用的管理：足够但不完美。

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本文引用的文献

1

Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection.《2019年丙型肝炎指南更新：美国肝病研究协会-美国传染病学会关于丙型肝炎病毒感染检测、管理及治疗的建议》

Hepatology. 2020 Feb;71(2):686-721. doi: 10.1002/hep.31060.

2

Efficacy and safety of new direct antiviral agents in hepatitis C virus-infected patients with diffuse large B-cell non-Hodgkin's lymphoma.新型直接抗病毒药物在丙型肝炎病毒感染伴弥漫大 B 细胞非霍奇金淋巴瘤患者中的疗效和安全性。

Hepatology. 2018 Jan;67(1):48-55. doi: 10.1002/hep.29364. Epub 2017 Nov 24.

3

Antiviral Treatment of HCV-Infected Patients with B-Cell Non-Hodgkin Lymphoma: ANRS HC-13 Lympho-C Study.丙型肝炎病毒感染合并B细胞非霍奇金淋巴瘤患者的抗病毒治疗：ANRS HC-13淋巴-C研究。

PLoS One. 2016 Oct 17;11(10):e0162965. doi: 10.1371/journal.pone.0162965. eCollection 2016.

4

NCCN Guidelines Insights: Non-Hodgkin's Lymphomas, Version 3.2016.NCCN 指南解读：非霍奇金淋巴瘤，第 3.2016 版。

J Natl Compr Canc Netw. 2016 Sep;14(9):1067-79. doi: 10.6004/jnccn.2016.0117.

5

HCV-associated B-cell non-Hodgkin lymphomas and new direct antiviral agents.丙型肝炎病毒相关的B细胞非霍奇金淋巴瘤与新型直接抗病毒药物

Liver Int. 2015 Oct;35(10):2222-7. doi: 10.1111/liv.12897. Epub 2015 Jul 15.

6

Regression of an HCV-associated disseminated marginal zone lymphoma under IFN-free antiviral treatment.无干扰素抗病毒治疗下丙型肝炎病毒相关播散性边缘区淋巴瘤的消退

Blood. 2015 Apr 9;125(15):2446-7. doi: 10.1182/blood-2014-12-618652.

7

Antiviral therapy is associated with a better survival in patients with hepatitis C virus and B-cell non-Hodgkin lymphomas, ANRS HC-13 lympho-C study.抗病毒治疗与丙型肝炎病毒和 B 细胞非霍奇金淋巴瘤患者的生存改善相关，ANRS HC-13 淋巴 C 研究。

Am J Hematol. 2015 Mar;90(3):197-203. doi: 10.1002/ajh.23889. Epub 2014 Nov 24.

8

Rapid clearance of HCV-related splenic marginal zone lymphoma under an interferon-free, NS3/NS4A inhibitor-based treatment. A case report.在无干扰素、基于 NS3/NS4A 抑制剂的治疗下，HCV 相关脾边缘区淋巴瘤快速清除。一例报告。

J Hepatol. 2015 Jan;62(1):234-7. doi: 10.1016/j.jhep.2014.09.031. Epub 2014 Oct 5.

9

Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus.美国丙型肝炎病毒感染退伍军人患非霍奇金淋巴瘤及淋巴增殖性前驱疾病的风险

JAMA. 2007 May 9;297(18):2010-7. doi: 10.1001/jama.297.18.2010.

10

Systematic review: regression of lymphoproliferative disorders after treatment for hepatitis C infection.系统评价：丙型肝炎感染治疗后淋巴增生性疾病的消退

Aliment Pharmacol Ther. 2005 Mar 15;21(6):653-62. doi: 10.1111/j.1365-2036.2005.02395.x.

HIV合并感染中丙型肝炎病毒与弥漫性大B细胞淋巴瘤的直接抗病毒药物联合治疗：一例报告

Concomitant Treatment of Hepatitis C Virus and Diffuse Large B-Cell Lymphoma with Direct-Acting Antivirals in HIV Coinfection: A Case Report.

作者信息

Gallipani Alyssa, Cha Agnes, Berkowitz Leonard, Bakshi Anjali

机构信息

1 Corporate Pharmacy, RWJ Barnabas Health, West Orange, NJ, USA.

2 Arnold & Marie Schwartz College of Pharmacy, Brooklyn, NY, USA.

出版信息

J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958218822062. doi: 10.1177/2325958218822062.

DOI:10.1177/2325958218822062

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6748524/

Abstract

This report describes a case of concomitant treatment of advanced diffuse large B-cell lymphoma with chemoimmunotherapy along with direct-acting antivirals for hepatitis C virus in a patient coinfected with HIV. The patient tolerated gemcitabine, dexamethasone, cisplatin, and rituximab and achieved sustained virologic response after treatment with ledipasvir/sofosbuvir.

摘要

本报告描述了一例同时感染HIV的患者，采用化疗免疫疗法联合直接作用抗病毒药物治疗丙型肝炎病毒，同时治疗晚期弥漫性大B细胞淋巴瘤的病例。该患者耐受吉西他滨、地塞米松、顺铂和利妥昔单抗，并在接受来迪派韦/索磷布韦治疗后实现了持续病毒学应答。