Department of Medicine, Faculty of Medicine, University of Lleida, Catalunya, Spain.
Cardiac Imaging Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, CIBERCV, Spain.
Med Hypotheses. 2019 Mar;124:56-59. doi: 10.1016/j.mehy.2019.02.012. Epub 2019 Feb 2.
The atrioventricular node (AV) is considered the electrical connection between the atria and ventricles. There is an electrical pause between activation of the atria and the ventricles (PR segment), but to date the mechanism responsible for this interruption remains unclear. The present communication focuses on the hypothesis that magnetic field dynamics could provide the answer. Proof of this hypothesis is that in Wolff-Parkinson-White syndrome, where there is physical connection between the atria and ventricles (bundle of Kent), there is electrical AV continuity, no PR segment is detected, and catheter ablation of the abnormal bundle restores AV discontinuity. Spontaneous initiation of the heart at the level of the sinus node, the pacemaker of the heart, could also be explained via field dynamics. The known transmembrane pacemaker protein CHN4, present in both sinoatrial and AV nodal cells, could interact with field information to provide specificity in an electronic key-to-lock mechanism interaction.
房室结（AV）被认为是心房和心室之间的电连接。心房和心室的激活之间存在电暂停（PR 段），但迄今为止，导致这种中断的机制仍不清楚。本通讯的重点是磁场动力学可以提供答案的假设。该假设的证据是，在房室结（肯特束）存在心房和心室之间的物理连接的沃夫-帕金森-怀特综合征中，存在电 AV 连续性，未检测到 PR 段，并且异常束的导管消融恢复 AV 不连续性。心脏在窦房结（心脏起搏器）水平的自发启动也可以通过场动力学来解释。已知存在于心房和房室结细胞中的跨膜起搏器蛋白 CHN4 可以与场信息相互作用，以在电子钥匙-锁机制相互作用中提供特异性。
