Pallet Nicolas, Bastard Jean-Philippe, Claeyssens Sophie, Fellahi Soraya, Delanaye Pierre, Piéroni Laurence, Caussé Elizabeth
Service de biochimie, Hôpital européen Georges Pompidou, AP-HP, Paris, France.
UF Biomarqueurs inflammatoires et métaboliques, Service de biochimie et hormonologie, Hôpital Tenon, AP-HP, Paris, France.
Ann Biol Clin (Paris). 2019 Feb 1;77(1):13-25. doi: 10.1684/abc.2018.1401.
The typing of proteinuria is one of the complementary examinations carried out during the exploration of proteinuria. It aims to separate and identify the different proteins, or fractions of proteins, that make up proteinuria. The nature and relative importance of the proteins present reflect the location of the renal involvement and help to determine the etiology. The typing of a proteinuria also allows the detection of a monoclonal component in urine and its quantification. Finally, it allows highlighting the existence of a proteinuria of overload that can occur in the absence of kidney damage. Many methods allow the typing of proteinuria, and these have benefited in recent years from technological advances. The purpose of this review is to summarize typing methods currently used, their benefits and limitations, and the help that these diagnostic tools can provide to the management of patients.
蛋白尿分型是在蛋白尿检查过程中进行的补充检查之一。其目的是分离和鉴定构成蛋白尿的不同蛋白质或蛋白质组分。所存在蛋白质的性质和相对重要性反映了肾脏受累的部位，并有助于确定病因。蛋白尿分型还可检测尿液中的单克隆成分并对其进行定量。最后，它能突出显示在无肾脏损害情况下可能出现的超负荷蛋白尿的存在。有多种方法可用于蛋白尿分型，近年来这些方法受益于技术进步。本综述的目的是总结目前使用的分型方法、其优点和局限性，以及这些诊断工具可为患者管理提供的帮助。
