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兰索拉唑对短肠综合征患者胃内pH值控制的影响。

Effect of Lansoprazole on the Control of the Intragastric pH in a Patient with Short Bowel Syndrome.

作者信息

Yoshioka Masato, Watanabe Tasuku, Iida Masatake, Nakagawa Yasuhiko, Uchinami Hiroshi, Watanabe Go, Abe Yuki, Yagi Fumitaka, Yokoyama Naohiro, Yamamoto Yuzo

机构信息

Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, Japan.

出版信息

Intern Med. 2019 Jun 15;58(12):1723-1726. doi: 10.2169/internalmedicine.2221-18. Epub 2019 Feb 25.

DOI:10.2169/internalmedicine.2221-18
PMID:30799357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6630122/
Abstract

A 40-year-old man suffered from short bowel syndrome. Since a large amount of intestinal output and watery diarrhea hampered his quality of life, we tried to control the intestinal output by reducing the secretion of gastric acid with lansoprazole. Because the small intestine was only 10 cm in length and effective absorption of oral lansoprazole was doubtful, we monitored his intragastric pH for 24 hours and confirmed that the holding time above pH 3.0 was 14.5 hours (60.4%). He spent his home life eating porridge during the day, and receiving total parenteral nutrition of 1,100 mL/day at night while taking lansoprazole as an oral tablet (30 mg) once a day.

摘要

一名40岁男性患有短肠综合征。由于大量肠液排出和水样腹泻影响了他的生活质量，我们尝试用兰索拉唑减少胃酸分泌来控制肠液排出。由于小肠长度仅为10厘米，口服兰索拉唑的有效吸收情况存疑，我们对他进行了24小时胃内pH监测，证实pH高于3.0的持续时间为14.5小时（60.4%）。他白天在家吃粥，晚上接受1100毫升/天的全胃肠外营养，同时每天口服一次兰索拉唑片（30毫克）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2254/6630122/9307d791b75e/1349-7235-58-1723-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2254/6630122/daae0397a2ea/1349-7235-58-1723-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2254/6630122/9307d791b75e/1349-7235-58-1723-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2254/6630122/daae0397a2ea/1349-7235-58-1723-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2254/6630122/9307d791b75e/1349-7235-58-1723-g002.jpg

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本文引用的文献

1
Spectrum of short bowel syndrome in adults: intestinal insufficiency to intestinal failure.成人短肠综合征的范围：从肠道功能不全到肠道衰竭。
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Aliment Pharmacol Ther. 2008 Jan 1;27(1):66-71. doi: 10.1111/j.1365-2036.2007.03545.x. Epub 2007 Oct 8.
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Acid-suppressive effects of rabeprazole, omeprazole, and lansoprazole at reduced and standard doses: a crossover comparative study in homozygous extensive metabolizers of cytochrome P450 2C19.雷贝拉唑、奥美拉唑和兰索拉唑在降低剂量和标准剂量下的抑酸作用：细胞色素P450 2C19纯合子广泛代谢者的交叉对照研究
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AGA technical review on short bowel syndrome and intestinal transplantation.美国胃肠病学会关于短肠综合征与肠道移植的技术综述
Gastroenterology. 2003 Apr;124(4):1111-34. doi: 10.1016/s0016-5085(03)70064-x.
8
Comparison of lansoprazole and famotidine for gastric acid inhibition during the daytime and night-time in different CYP2C19 genotype groups.不同CYP2C19基因型组中兰索拉唑和法莫替丁在白天和夜间抑制胃酸分泌的比较。
Aliment Pharmacol Ther. 2002 Apr;16(4):837-46. doi: 10.1046/j.1365-2036.2002.01229.x.
9
Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers.兰索拉唑对正常男性志愿者胃内pH值及胃酸分泌的作用持续时间。
Aliment Pharmacol Ther. 2001 Jan;15(1):105-13. doi: 10.1046/j.1365-2036.2001.00831.x.
10
Acid-inhibitory effects of omeprazole and lansoprazole in Helicobacter pylori-negative healthy subjects.奥美拉唑和兰索拉唑对幽门螺杆菌阴性健康受试者的抑酸作用。
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