Sakaguchi M, Ashida K, Umegaki E, Miyoshi H, Katsu K
Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan.
J Clin Gastroenterol. 1995;20 Suppl 2:S27-31. doi: 10.1097/00004836-199506002-00008.
We studied the action on acid secretion of lansoprazole compared with famotidine by 24-h intragastric pH monitoring, evaluated its clinical effects prospectively, and assessed the importance of acid inhibition in gastric ulcer patients. Twenty symptomatic patients with active gastric ulcers diagnosed by endoscopy were assigned to a lansoprazole (LAN) group (lansoprazole 30 mg q.d., n = 10) or a famotidine (FAM) group (famotidine 20 mg b.i.d., n = 10). There were no differences between the groups in pretreatment pH profiles or background factors such as age, sex, smoking, previous ulcer therapy, ulcer site, or Helicobacter pylori infection. The FAM group showed a continuous increase in intragastric pH during the night, with low pH values except for a transient increase associated with food intake during the day. However, the LAN group showed a more neutral pH throughout the day, with pH-3 holding time ratios of 99.0% for 24 h, 98.3% at night, and 99.8% during the day, compared with 68.0, 76.5, and 59.4%, respectively, in the FAM group. The healing rate was also higher in the LAN group. We conclude that inhibition of gastric acidity is important in ulcer therapy and that lansoprazole is superior to famotidine in promoting ulcer healing.
我们通过24小时胃内pH监测研究了兰索拉唑与法莫替丁对胃酸分泌的作用，前瞻性地评估了其临床效果，并评估了胃酸抑制在胃溃疡患者中的重要性。20例经内镜诊断为活动性胃溃疡的有症状患者被分为兰索拉唑（LAN）组（兰索拉唑30mg每日一次，n = 10）或法莫替丁（FAM）组（法莫替丁20mg每日两次，n = 10）。两组在治疗前的pH曲线或年龄、性别、吸烟、既往溃疡治疗史、溃疡部位或幽门螺杆菌感染等背景因素方面没有差异。FAM组夜间胃内pH持续升高，除白天与进食相关的短暂升高外，pH值较低。然而，LAN组全天pH更接近中性，24小时pH≥3的时间比例为99.0%，夜间为98.3%，白天为99.8%，而FAM组分别为68.0%、76.5%和59.4%。LAN组的愈合率也更高。我们得出结论，胃酸抑制在溃疡治疗中很重要，并且兰索拉唑在促进溃疡愈合方面优于法莫替丁。
