Duffy B, Pencharz P
Am J Clin Nutr. 1986 Jan;43(1):108-11. doi: 10.1093/ajcn/43.1.108.
We have examined the effect of the route of feeding (intravenous versus enteral) on the protein metabolism of postsurgical human neonates. Twelve infants, birth weight 2.5 +/- 0.2 kg, gestational age 38 +/- 1 wk, were studied. The IV study was carried out 1-4 days after surgery at a postnatal age of 14 days and a weight of 2.6 +/- 0.2 kg. The repeat (oral) study was carried out 16 days later. Protein intakes were similar during both studies (2.7 g/kg/d). Energy intakes were within the requirement range for age and feeding route and were: IV, 85 +/- 4 kcal/kg/d; oral, 111 +/- 7 kcal/kg/d. Whole body protein metabolism was studied using a continuous infusion of 15N-glycine. Amino nitrogen flux, protein synthesis, and breakdown were 40% higher during the enteral than the IV studies (p less than 0.001). Skeletal muscle degradation was investigated by measuring urinary excretion of creatinine and N-T-methylhistidine. No differences were detected due to feeding route. We suggest that the differences seen in whole body protein turnover rates reflect the rapid growth and development of the gut in the enterally (rather than the IV) fed infant.
我们研究了喂养途径（静脉内喂养与肠内喂养）对手术后人类新生儿蛋白质代谢的影响。研究了12名婴儿，出生体重2.5±0.2千克，胎龄38±1周。静脉内喂养研究在出生后14天、体重2.6±0.2千克时于手术后1 - 4天进行。重复（口服）研究在16天后进行。两项研究期间蛋白质摄入量相似（2.7克/千克/天）。能量摄入量在年龄和喂养途径的需求范围内，分别为：静脉内喂养，85±4千卡/千克/天；口服，111±7千卡/千克/天。使用连续输注15N - 甘氨酸研究全身蛋白质代谢。肠内喂养期间的氨基氮通量、蛋白质合成和分解比静脉内喂养研究高40%（p<0.001）。通过测量肌酐和N - T - 甲基组氨酸的尿排泄量来研究骨骼肌降解。未检测到因喂养途径导致的差异。我们认为，全身蛋白质周转率的差异反映了肠内喂养（而非静脉内喂养）婴儿肠道的快速生长和发育。
