Department of Obstetrics and Gynecology, IVF Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Obstetrics and Gynecology, IVF Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China,
Gynecol Obstet Invest. 2019;84(5):445-454. doi: 10.1159/000497203. Epub 2019 Feb 21.
This is a case series reporting live births following in vitro fertilization (IVF) after fertility-sparing surgery in patients with borderline ovarian tumors (BOTs). Seventeen patients, in whom fertility-sparing surgery for BOTs followed by IVF was performed from July 1, 2011 to September 30, 2017, in our IVF center, were included. Here we retrospectively present their BOT characteristics and clinical outcomes of assisted reproduction technology (ART) and then discuss the literature on management of patients with BOTs after fertility-sparing surgery. The study sample of 17 patients started IVF-assisted reproduction within a median of 24 months after fertility-sparing surgery. Eight patients achieved live births after IVF followed by fresh or frozen-thawed embryo transfer, and one is currently pregnant after the second IVF treatment. Four of these 17 women experienced 6 recurrences of BOTs after IVF and delivery in a median of 29 months of follow-up. The literature reports a pooled estimate of 63.5% for pregnancy and 21.7% for recurrence of BOTs in patients with the same condition. Pregnancy outcomes of IVF in these women are usually better than those of generally infertile women. Moreover, our review of the literature suggests that ART has no negative impact on the prognosis of BOTs.
这是一系列病例报告，介绍了在体外受精（IVF）之前进行保留生育功能手术的交界性卵巢肿瘤（BOT）患者的活产情况。2011 年 7 月 1 日至 2017 年 9 月 30 日，我们的 IVF 中心对 17 名交界性卵巢肿瘤患者进行了保留生育功能手术和 IVF，本研究回顾了这些患者的 BOT 特征和辅助生殖技术（ART）的临床结局，并讨论了关于保留生育功能手术后 BOT 患者管理的文献。17 名患者中有 8 名在保留生育功能手术后 24 个月中位数内开始接受 IVF 辅助生殖，其中 8 名患者在新鲜或冷冻解冻胚胎移植后实现了活产，1 名患者在第二次 IVF 治疗后目前已怀孕。在这些患者中，有 4 名在 IVF 和分娩后中位随访 29 个月时经历了 6 次 BOT 复发。文献报告，在具有相同条件的患者中，妊娠的累积估计值为 63.5%，BOT 复发的累积估计值为 21.7%。这些女性的 IVF 妊娠结局通常优于一般不孕女性。此外，我们对文献的回顾表明，ART 对 BOT 的预后没有负面影响。
