葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症儿童溶血过程中T淋巴细胞亚群的变化。

T-lymphocyte subpopulation changes during hemolysis in glucose-6-phosphate dehydrogenase (G6PD)-deficient children.

作者信息

Schilirò G, Minniti C, Sciotto A, Bellino A, Russo A

出版信息

Am J Hematol. 1986 Feb;21(2):173-6. doi: 10.1002/ajh.2830210206.

Abstract

Lymphocyte subpopulations were studied by means of sheep red blood cell (SRC)-rosetting technique and OKT11, OKT3, OKT4, and OKT8 monoclonal antibodies in ten Sicilian glucose-6-phosphate dehydrogenase-deficient children during the hemolytic crisis due to fava bean ingestion. The number of SRC-rosetting lymphocytes was significantly reduced, while the number of OKT3-positive cells was normal. An inversion of the OKT4/OKT8 ratio was observed, due to a decrease of OKT4-positive cells and an increase of OKT8-positive cells. All these abnormalities reverted to normal in the four children studied after recovery.

摘要

采用绵羊红细胞（SRC）玫瑰花结技术以及OKT11、OKT3、OKT4和OKT8单克隆抗体，对10名西西里岛葡萄糖-6-磷酸脱氢酶缺乏症儿童在因食用蚕豆引发溶血危机期间的淋巴细胞亚群进行了研究。SRC玫瑰花结淋巴细胞数量显著减少，而OKT3阳性细胞数量正常。由于OKT4阳性细胞减少和OKT8阳性细胞增加，观察到OKT4/OKT8比值倒置。在恢复后对4名儿童进行研究发现，所有这些异常均恢复正常。