一种罕见的睾丸肿瘤：原发性类癌肿瘤。
A rare testicular tumor: primary carcinoid tumor.
作者信息
Darré Tchin, Doukouré Brahima, Kouyaté Mohamed, Djiwa Toukilnan, Kwamé Doh, Napo-Koura Gado
机构信息
Department of Pathology, University Teaching Hospital of Lomé, Togo.
Department of Pathology, University Teaching Hospital of Cocody, Abidjan, Ivory Coast.
出版信息
Tumori. 2019 Dec;105(6):NP20-NP23. doi: 10.1177/0300891619832263. Epub 2019 Feb 24.
BACKGROUND
Primary carcinoid tumors are rare and constitute 0.23% of all testicular tumors. We report a case of primary carcinoid tumor of testicular localization, with a review of the literature.
CASE PRESENTATION
A 29-year-old man, without specific ascendants, consulted the urology department for progressive scrotal swelling of 6 months, associated with pain. After surgery, histology showed diffuse tumor proliferation composed of small round monotone cells with hyperchromatic nuclei evoking undifferentiated carcinoma. Immunohistochemistry showed that tumor cells were positive for chromogranin A and negative for placental alkaline phosphatase and α-fetoprotein.
CONCLUSION
Primary neuroendocrine carcinoma of the testis is a very rare malignant tumor. Immunohistochemistry contributes to its diagnosis in relation to other metastatic neuroendocrine carcinomas, carcinoid tumor teratomas, seminoma, and Sertoli cells.
背景
原发性类癌肿瘤罕见，占所有睾丸肿瘤的0.23%。我们报告一例睾丸原发性类癌肿瘤病例，并对相关文献进行综述。
病例介绍
一名29岁男性，无特殊家族史，因阴囊进行性肿胀6个月并伴有疼痛就诊于泌尿外科。手术后，组织学检查显示肿瘤呈弥漫性增殖，由小的圆形单一细胞组成，细胞核深染，提示未分化癌。免疫组织化学检查显示肿瘤细胞嗜铬粒蛋白A呈阳性，胎盘碱性磷酸酶和甲胎蛋白呈阴性。
结论
睾丸原发性神经内分泌癌是一种非常罕见的恶性肿瘤。免疫组织化学有助于将其与其他转移性神经内分泌癌、类癌性畸胎瘤、精原细胞瘤和支持细胞瘤进行鉴别诊断。
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