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叶片乙醇提取物对佐剂和角叉菜胶处理大鼠的抗炎作用。

Anti-inflammatory Effect of Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats.

机构信息

Department of Science, CMJ University Jorabat, Raibhoi, Meghalaya-793101, India.

Vinayaka College of Pharmacy, Kullu (HP), India.

出版信息

Antiinflamm Antiallergy Agents Med Chem. 2020;19(2):103-112. doi: 10.2174/1871523018666190222120127.

DOI:10.2174/1871523018666190222120127
PMID:30799799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7475893/
Abstract

BACKGROUND

Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.

METHODS

In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund's adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni's test was used for statistical analysis.

RESULTS

WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed.

CONCLUSION

These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.

摘要

背景

辣蓼大丁草被传统用于治疗与关节炎相关的炎症。

方法

在本研究中，辣蓼大丁草（WFE）叶乙醇提取物通过口服给予 200mg/kg 剂量，在 Sprague Dawley 大鼠中评估其抗炎活性。通过使用角叉菜胶诱导的爪肿胀、弗氏完全佐剂（FA）和单碘乙酸盐（MIA）诱导的关节炎作为动物模型来研究炎症。在给予 FA 的动物的血液样本中估计血清肿瘤坏死因子-α（TNF-α）。采用单因素方差分析（One Way ANOVA），随后进行 Bonferroni 检验进行统计分析。

结果

WFE 显著降低了角叉菜胶诱导的爪肿胀和 FA 诱导的关节炎中爪厚度（P<0.05，P<0.001）。在 MIA 诱导的关节炎中，膝关节直径显著减小（P<0.001），并观察到对升高的 TNF-α的抑制作用（P<0.001）。

结论

这些结果表明，WFE 对 TNF-α和角叉菜胶爪肿胀具有抑制作用，这可能证明其在炎症情况下的传统用途是合理的。因此，该研究表明，辣蓼大丁草的叶子通过防止不同动物模型中的炎症发挥抗炎活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/721fbe2d772f/AIAAMC-19-103_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/3a58460d7c79/AIAAMC-19-103_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/0480fa948105/AIAAMC-19-103_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/8bc906384ead/AIAAMC-19-103_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/26d52f2b38dd/AIAAMC-19-103_F4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/4b7816da79ca/AIAAMC-19-103_F4b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/721fbe2d772f/AIAAMC-19-103_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/3a58460d7c79/AIAAMC-19-103_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/0480fa948105/AIAAMC-19-103_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/8bc906384ead/AIAAMC-19-103_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/26d52f2b38dd/AIAAMC-19-103_F4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/4b7816da79ca/AIAAMC-19-103_F4b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f142/7475893/721fbe2d772f/AIAAMC-19-103_F5.jpg

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